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Protein Overview: VAN1

General Information:
Name(s) found: VAN1 / YML115C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 535 amino acids

    Gene Ontology:
    Cellular Component: cis-Golgi network [TASLink to PubMed article]
    membrane [TASLink to PubMed article]
    alpha-1,6-mannosyltransferase complex [IPILink to PubMed article]
    Biological Process: protein amino acid N-linked glycosylation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: mannosyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGMFFNLRSN IKKKAMDNGL SLPISRNGSS NNIKDKRSEH NSNSLKGKYR YQPRSTPSKF  60
   61 QLTVSITSLI IIAVLSLYLF ISFLSGMGIG VSTQNGRSLL GSSKSSENYK TIDLEDEEYY 120
  121 DYDFEDIDPE VISKFDDGVQ HYLISQFGSE VLTPKDDEKY QRELNMLFDS TVEEYDLSNF 180
  181 EGAPNGLETR DHILLCIPLR NAADVLPLMF KHLMNLTYPH ELIDLAFLVS DCSEGDTTLD 240
  241 ALIAYSRHLQ NGTLSQIFQE IDAVIDSQTK GTDKLYLKYM DEGYINRVHQ AFSPPFHENY 300
  301 DKPFRSVQIF QKDFGQVIGQ GFSDRHAVKV QGIRRKLMGR ARNWLTANAL KPYHSWVYWR 360
  361 DADVELCPGS VIQDLMSKNY DVIVPNVWRP LPTFLGTEQP YDLNSWMESQ EALALAKTLD 420
  421 EDDVIVEGYA EYPTWRVHLA YIRDAEGDPN EAVDLDGVGG VSILAKAKIF RNGVQFPAFT 480
  481 FENHAETEAF GKMAKKMGYR VGGLPHYTIW HIYEPSDDDL KEIASREREK RRQSE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) KTR3 MNN9 SLC1 VAN1 WBP1
    View Details Qiu et al. (2008) ANP1 GNT1 HOC1 KRE2 KTR1 MNN10 MNN11 MNN9 OCH1 VAN1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VAN1 Huh WK, et al. (2003)
    View Data VAN1 and ANP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..121] deduced N/A No confident structure predictions are available.
    2 View Details [122..535] Pfam 1000.0 Anp1 No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • UDP-glycosyltransferase activity
    		•  6.01354989568484 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  5.66606808201136 bayes_pls_golite062009
  • alpha-1,2-mannosyltransferase activity
    		•  5.62955108548526 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  5.60505224219681 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  5.1732667004955 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  4.21261757812439 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  4.02812104984198 bayes_pls_golite062009
  • transferase activity
    		•  2.3313878748424 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.79751747857925 bayes_pls_golite062009
  • catalytic activity
    		•  1.73979371332125 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.47767908405723 bayes_pls_golite062009
  • N-acetyllactosamine synthase activity
    		•  0.925872529464618 bayes_pls_golite062009
  • lactose synthase activity
    		•  0.925872529464618 bayes_pls_golite062009
  • binding
    		•  0.61043334112269 bayes_pls_golite062009
  • alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
    		•  0.386636074342689 bayes_pls_golite062009
  • protein binding
    		•  0.18104648403595 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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