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Protein Overview: MDH2

General Information:
Name(s) found: MDH2 / YOL126C [SGD]
Description(s) found:
Found 14 descriptions.
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  • Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 423 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    cytosol [TASLink to PubMed article]
    Biological Process: gluconeogenesis [IEPLink to PubMed article][TASLink to PubMed article]
    malate metabolic process [TASLink to PubMed article]
    Molecular Function: L-malate dehydrogenase activity [IMPLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILLLILFPC IYFLPFCINR TVRSSPEYSA ADYYKSSIQY HKSYSNMPHS VTPSIEQDSL  60
   61 KIAILGAAGG IGQSLSLLLK AQLQYQLKES NRSVTHIHLA LYDVNQEAIN GVTADLSHID 120
  121 TPISVSSHSP AGGIENCLHN ASIVVIPAGV PRKPGMTRDD LFNVNAGIIS QLGDSIAECC 180
  181 DLSKVFVLVI SNPVNSLVPV MVSNILKNHP QSRNSGIERR IMGVTKLDIV RASTFLREIN 240
  241 IESGLTPRVN SMPDVPVIGG HSGETIIPLF SQSNFLSRLN EDQLKYLIHR VQYGGDEVVK 300
  301 AKNGKGSATL SMAHAGYKCV VQFVSLLLGN IEQIHGTYYV PLKDANNFPI APGADQLLPL 360
  361 VDGADYFAIP LTITTKGVSY VDYDIVNRMN DMERNQMLPI CVSQLKKNID KGLEFVASRS 420
  421 ASS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) EXG1 FAA4 MDH2 MET18 PDI1 RFC2 RPN5 YIL108W

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC48 MDH2 1 Unpublished Fields Lab Data
    View Screen CUS1 MDH2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..423] PSI-BLAST 621.529817 Malate dehydrogenase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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