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Protein Overview: MDM20

General Information:
Name(s) found: MDM20 / YOL076W [SGD]
Description(s) found:
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  • gi|6324497|ref|NP_014566.1| Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly; Mdm20p [Saccharomyces cerev [NCBI NR]
  • gi|51013611|gb|AAT93099.1| YOL076W [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2498298|sp|Q12387.1|MDM20_YEAST RecName: Full=N-terminal acetyltransferase B complex subunit MDM20; Short=NatB complex subunit MDM20; AltName: Full=Mitochondrial distribution and morphology protein 20; AltName: Full=Dislikes extra CIN8 protein 1 [NCBI NR]
  • pir||S66769 probable membrane protein YOL076w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1419907|emb|CAA99086.1| DEC1 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1322287|gb|AAB00196.1| Mdm20p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1033068|gb|AAA79781.1| Dec1p [NCBI NR]
  • N-terminal acetyltransferase B complex subunit MDM20 OS=Saccharomyces cerevisiae GN=MDM20 PE=1 SV=1 [Swiss-Prot]
  • (Q12387) DEC1 protein (MDM20 protein) [Swiss-Prot]
  • MDM20 Necessary for mitochondrial inheritance and organisation of the actin cytoskeleton [mips]
  • Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly [SGD]
  • Chr XV from 187023-189413 [hmr_yeast5_DM3-1_pombe.fasta]
  • MDM20, Chr XV from 187023-189413 [yeast_orfs2]
  • MDM20 SGDID:S0005436, Chr XV from 187023-189413, Verified ORF [yeastflysequest.fasta]
  • Mdm20p [Saccharomyces cerevisiae]gi|51013611|gb|AAT93099.1| YOL076W [Saccharomyces cerevisiae]gi|1419907|emb|CAA99086.1| DEC1 [Saccharomyces cerevisiae]gi|2132841|pir||S66769 probable membrane protein YOL076w - yeast (Saccharomyces cerevisiae)gi|13222 [nrdb_11152004_Chlamydomonas]
  • MDM20 SGDID:S000005436, Chr XV from 187023-189413, Verified ORF, "Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and o [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MDM20 SGDID:S000005436, Chr XV from 187024-189414, Verified ORF, "Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and o [yeast-contam.fasta]
  • MDM20 SGDID:S000005436, Chr XV from 187024-189414, Verified ORF, "Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • YOL076W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Mdm20p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; involved in mit [nr-271106-contam.fasta]
  • Dec1p [nr-271106-contam.fasta]
  • DEC1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • N-terminal acetyltransferase B complex subunit MDM20 (NatB complex subunit MDM20) (Mitochondrial distribution and morphology protein 20) (Dislikes extra CIN8 protein 1) [nr-271106-contam.fasta]
  • MDM20 SGDID:S000005436, Chr XV from 187024-189414, Verified ORF, "Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly" [yeast-bovrabprots.fasta]
  • MDM20 SGDID:S000005436, Chr XV from 187024-189414, Verified ORF, "Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; involved in mitochondrial inheritance and actin assembly" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • N-terminal acetyltransferase B complex subunit MDM20 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDM20 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MDM20 SGDID:S000005436, Chr XV from 187024-189414, Genome Release 64-1-1, Verified ORF, "Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly" [yeast-030211-contam.fasta]
  • MDM20 SGDID:S000005436, Chr XV from 187024-189414, Genome Release 64-2-1, Verified ORF, "Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly" [20141208_orf_trans.fasta]
  • YOL076W SGDID:S000005436, Chr XV from 187024-189414, Genome Release 64-1-1, Verified ORF, "Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 796 amino acids

    Gene Ontology:
    Cellular Component: NatB complex [TASLink to PubMed article]
    Biological Process: mitochondrion inheritance [IGILink to PubMed article][IMPLink to PubMed article]
    cytoskeleton organization [IMPLink to PubMed article]
    N-terminal peptidyl-methionine acetylation [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: peptide alpha-N-acetyltransferase activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDKIQEEIL GLVSRSNFKQ CYAKLGQLQK QFPNALYFKI LETYVKFKQS PGKFDYNKLL  60
   61 EEPYGLKGTT ITGDTRSLEF LHNFFVELGK YDEALHVYER GNFKFPSYEL SYHWFMKALE 120
  121 DSNYNQMSKA SLQLAKYSDS GNLPKRAYYF WNAISILAVS RFQENTLSDP KKILLSRLAR 180
  181 QSLLDLKPFQ NVQEIIVYCL VLDELFPQSR EISEEIVAIT FANFDTSVNL YLKNFILKHT 240
  241 KLLNSPQKLF EVCSKLIEKG LDDYELITNL IDAAYKLSKS KDEVKQWIDE NLGDSRNTRL 300
  301 ARLKLDIMYT DSVSESSLSY YLSKYHNKPC CSIDLNHYSG HINIDMLKSI MSKYDPEDKD 360
  361 LIHHCNILEL GLIGSDSINN YNKFKGTLEK KSVTDYSSCS TFLLEIVKDK CKKTNPELKD 420
  421 VLLCITILEN YQAKDPHNFD TMCWLIVLYM YLGLVPDAYF HFINLKIKNV QTDSLDYMIF 480
  481 SRFSTLFPNK QSDFYSKTFH EHNNLYDTSL ANLPRYIQVA FERNSYSKIL GMLEMRDKLM 540
  541 KSYTRWTKTL ENLQFSRLCN DKRGHLLQKL HEDWRSLEMT QSVSFSDNRD FSILDENFAQ 600
  601 FLNRGKILEY ANLNEESIFL TLIRELIIEA LPNGEKTEQI SALLKKLPSI NLEELLNNNL 660
  661 TEVESASFLI FFEIYENNGK NLHDLISRLM KVPINAKQNW MVSHTYLTKM ATLKTLDSLK 720
  721 RIKDKEIQKL IKNSLKELRS CCDDVFKGYS KALVQAYEEL KKDECGNLLK ELDVKAENVK 780
  781 NIKNSLLGIQ KSVRNL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MDM20 NAT3
    View Details Krogan NJ, et al. (2006) MDM20 NAT3
    View Details Qiu et al. (2008) ARD1 MAK10 MAK3 MAK31 MDM20 NAT1 NAT3 NAT5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MDM20 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..587] MSA 5.00787 View MSA. No confident structure predictions are available.
    2 View Details [588..796] deduced N/A No confident structure predictions are available.
    3 View Details [661..796] deduced N/A Confident ab initio structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle