Protein Overview: COS10

General Information:
Name(s) found:	COS10 / YNR075W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|805058\|emb\|CAA60488.1\| N3820 [Saccharomyces cerevisiae] [NCBI NR] gi\|6324403\|ref\|NP_014473.1\| Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos10p [Saccharomyces cerevisiae] [NCBI NR] gi\|1730702\|sp\|P52924.1\|COS10_YEAST RecName: Full=Protein COS10 [NCBI NR] gi\|1302614\|emb\|CAA96359.1\| COS10 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S54057 probable membrane protein YNR075w - yeast (Saccharomyces cerevisiae) [NCBI NR] (P52924) COS10 protein [Swiss-Prot] Protein COS10 OS=Saccharomyces cerevisiae GN=COS10 PE=1 SV=1 [Swiss-Prot] COS10 Member of a family of conserved, often subtelomerically-encoded proteins [mips] Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [SGD] Chr XIV from 779911-781035 [hmr_yeast5_DM3-1_pombe.fasta] COS10, Chr XIV from 779911-781035 [yeast_orfs2] COS10 SGDID:S0005358, Chr XIV from 779913-781037, Verified ORF [yeastflysequest.fasta] COS10 SGDID:S0005358, Chr XIV from 779914-781038, Verified ORF [10112005cervSGD.fasta] Cos10p [Saccharomyces cerevisiae]gi\|805058\|emb\|CAA60488.1\| N3820 [Saccharomyces cerevisiae]gi\|1302614\|emb\|CAA96359.1\| COS10 [Saccharomyces cerevisiae]gi\|1078142\|pir\|\|S54057 probable membrane protein YNR075w - yeast (Saccharomyces cerevisiae)gi\|1730702 [nrdb_11152004_Chlamydomonas] COS10 SGDID:S000005358, Chr XIV from 779916-781040, Verified ORF, "Protein of unknown function, member of a family of conserved, often subtelomerically-encoded proteins" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] COS10 SGDID:S000005358, Chr XIV from 779916-781040, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [yeast-contam.fasta] Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; Cos10p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein COS10 [nr-271106-contam.fasta] N3820 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] COS10 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] COS10 SGDID:S000005358, Chr XIV from 779917-781041, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] [chemostatdb.fasta] Protein COS10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COS10 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] COS10 SGDID:S000005358, Chr XIV from 779916-781040, Genome Release 64-1-1, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [yeast-030211-contam.fasta] COS10 SGDID:S000005358, Chr XIV from 779916-781040, Genome Release 64-2-1, Verified ORF, "Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [20141208_orf_trans.fasta] YNR075W SGDID:S000005358, Chr XIV from 779916-781040, Genome Release 64-1-1, Verified ORF, "Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	374 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [IDA] cytoplasm [IDA] endoplasmic reticulum [IDA ]
Biological Process:	endocytosis [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEEIRLLSS KGLETHSSFC LPEDIFRNRL TWLCSEIRNS GFWIWSLSWL PLAVWWGMAS  60
   61 TWFYPLLTSV VLILALIAIL PVVQIQYSKY TLSNQLTQLS KEIIKSAPGA YSADWDAVAI 120
  121 HFNSYLYENK AWKTAHFFFN GTDCQEAFRK TILEPAVLRR QNEDPRFSSI EILVPYTEDA 180
  181 VQVYFTKVNA QWRLIHGKKE CKLTMLENVK LPKETYRCKL AWSCQRIRIS FSPLDFLPDM 240
  241 SDFFICANLS PACLVSYWLI DIFFRMIDDF QNIRPKSMKV DDKMQYLSDI INEQGASPEK 300
  301 WDTIARKTNT RLFEKRVWKN EEFFFDGTDC QAFFERNFSS LLFSKKSASP RSLNVELWKY 360
  361 IQEAQLSCNY EPLP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#34 Asynchronous SPB prep	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	COS10	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..59]	MSA	1.020989	View MSA. No confident structure predictions are available.
2	View Details	[60..173]	Pfam	45.920819	No description for PF00674.9 was found. No confident structure predictions are available.
3	View Details	[174..251]	deduced	N/A	No confident structure predictions are available.
4	View Details	[252..374]	Pfam	51.537602	No description for PF00674.9 was found. No confident structure predictions are available.

Protein Overview: COS10

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: