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Protein Overview: TRM112

General Information:
Name(s) found: TRM112 / YNR046W [SGD]
Description(s) found:
Found 34 descriptions.
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  • Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 135 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: tRNA methylation [IMPLink to PubMed article]
    Molecular Function: zinc ion binding [ISSLink to PubMed article]
    tRNA (guanine-N2-)-methyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFLTTNFLK CSVKACDTSN DNFPLQYDGS KCQLVQDESI EFNPEFLLNI VDRVDWPAVL  60
   61 TVAAELGNNA LPPTKPSFPS SIQELTDDDM AILNDLHTLL LQTSIAEGEM KCRNCGHIYY 120
  121 IKNGIPNLLL PPHLV

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TRM11 TRM112
    View Details Krogan NJ, et al. (2006) TRM11 TRM112 TRM9
    View Details Gavin AC, et al. (2006) LYS9 TRM11 TRM112
    View Details Gavin AC, et al. (2002) LYS9 MTQ2 TRM11 TRM112 TRM9
    View Details Qiu et al. (2008) DIM1 GCD14 TRM1 TRM10 TRM112 TRM8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen EXO84 TRM112 2 Unpublished Fields Lab Data
    View Screen UBC7 TRM112 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TRM112 and SPC42 Hazbun TR, et al. (2003)
    View Data TRM112 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] Pfam 3.376751 Trm112p-like protein No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle