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Protein Overview: WHI3

General Information:
Name(s) found: WHI3 / YNL197C [SGD]
Description(s) found:
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  • gi|6324132|ref|NP_014202.1| RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage t [NCBI NR]
  • gi|600068|emb|CAA55511.1| N1382 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|465481|sp|P34761.1|WHI3_YEAST RecName: Full=Protein WHI3 [NCBI NR]
  • gi|393077|gb|AAA03320.1| Whi3p [NCBI NR]
  • pir||S50734 WHI3 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1302195|emb|CAA96092.1| WHI3 [Saccharomyces cerevisiae] [NCBI NR]
  • Protein WHI3 OS=Saccharomyces cerevisiae GN=WHI3 PE=1 SV=1 [Swiss-Prot]
  • WHI3 Protein involved in regulation of cell size [mips]
  • RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start [SGD]
  • Chr XIV from 267605-269590, reverse complement [yeastorf3.fasta]
  • Chr XIV from 269590-267605, reverse complement [yeastorf5.fasta]
  • (P34761) WHI3 protein [4932.FASTACCERV.txt]
  • WHI3, Chr XIV from 267605-269590, reverse complement [yeast_orfs2]
  • WHI3 SGDID:S0005141, Chr XIV from 269592-267607, reverse complement, Verified ORF [yeastflysequest.fasta]
  • RNA binding protein that binds to and sequesters the G1 cyclin CLN3 mRNA; regulates cell fate and dose-dependently inhibits passage through Start by regulating the critical cell size requirement necessary for cell cycle progression [Saccharomyces cerevisi [nrdb_11152004_Chlamydomonas]
  • WHI3 SGDID:S000005141, Chr XIV from 269594-267609, reverse complement, Verified ORF, "RNA binding protein that binds to and sequesters the G1 cyclin CLN3 mRNA; regulates cell fate and dose-dependently inhibits passage through Start by regulating the criti [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • WHI3 SGDID:S000005141, Chr XIV from 269594-267609, reverse complement, Verified ORF, "RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependent [yeast-contam.fasta]
  • Protein WHI3 [nr-271106-contam.fasta]
  • RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; Whi3p [Sacchar [nr-271106-contam.fasta]
  • Whi3p [nr-271106-contam.fasta]
  • WHI3 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • N1382 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • WHI3 SGDID:S000005141, Chr XIV from 269594-267609, reverse complement, Verified ORF, "RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Protein WHI3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=WHI3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • WHI3 SGDID:S000005141, Chr XIV from 269593-267608, Genome Release 64-1-1, reverse complement, Verified ORF, "RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start" [yeast-030211-contam.fasta]
  • WHI3 SGDID:S000005141, Chr XIV from 269593-267608, Genome Release 64-2-1, reverse complement, Verified ORF, "RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; regulates genes involved in the cell cycle, sister chromatid cohesion, and stress response; acts as a cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; Tpk1p (PKA) mediated phosphorylation (S568) inhibits Whi3p function, decreasing its interaction with CLN3 mRNA; regulates ploidy" [20141208_orf_trans.fasta]
  • YNL197C SGDID:S000005141, Chr XIV from 269593-267608, Genome Release 64-1-1, reverse complement, Verified ORF, "RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 661 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: cytoplasmic sequestering of protein [IMPLink to PubMed article]
    regulation of cell size [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    pseudohyphal growth [IMPLink to PubMed articleLink to PubMed article]
    invasive growth in response to glucose limitation [IMPLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSSVYFDQT GSFASSSDNV VSSTTNTHNI SPSHRSSLNL NTTSHPHEAS GRGSASGELY  60
   61 LNDTNSPLAI SSMLNTLALG SMPQDIASSN ISNHDNNIKG SYSLKLSNVA KDITLRECYA 120
  121 IFALAEGVKS IELQKKNSSS SITSASLEDE NDIFIIARFE LLNLAINYAV ILNSKNELFG 180
  181 PSFPNKTTVE IIDDTTKNLV SFPSSAIFND TSRLNKSNSG MKRPSLLSQR SRFSFSDPFS 240
  241 NDSPLSQQQS QQQQQQPQQP QQHSTQKHSP QQCNQQQVNS SIPLSSQGQV IGLHSNHSHQ 300
  301 DLSVESTIQT SDIGKSFLLR DNTEINEKIW GTSGIPSSIN GYMSTPQPST PTLEWGNTSA 360
  361 SQHGSSFFLP SAASTAIAPT NSNTSANANA SSNNGASNNG ANQALSASSQ QPMMQIGNTI 420
  421 NTSLTSSNSL PPYGLMSSQS QHISNMVNTS DMNITPQKQN RFMQQPQPEH MYPVNQSNTP 480
  481 QKVPPARLSS SRNSHKNNST TSLSSNITGS ASISQADLSL LARIPPPANP ADQNPPCNTL 540
  541 YVGNLPSDAT EQELRQLFSG QEGFRRLSFR NKNTTSNGHS HGPMCFVEFD DVSFATRALA 600
  601 ELYGRQLPRS TVSSKGGIRL SFSKNPLGVR GPNSRRGGSG NPNPNVNMLS SYNSNVGHIK 660
  661 N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data WHI3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] deduced N/A No confident structure predictions are available.
    2 View Details [100..504] ORFEUS 10.98 RBP1
    3 View Details [505..661] PSI-BLAST 39.522879 Poly(A)-binding protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • nucleic acid binding
    		•  3.64594243387558 bayes_pls_golite062009
  • binding
    		•  3.00411894202318 bayes_pls_golite062009
  • mRNA binding
    		•  2.76744192669109 bayes_pls_golite062009
  • RNA binding
    		•  2.41328743949172 bayes_pls_golite062009
  • protein binding
    		•  1.12215421354121 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.737458867828906 bayes_pls_golite062009
  • DNA binding
    		•  0.691258294213766 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.599389001184667 bayes_pls_golite062009
  • translation regulator activity
    		•  0.38120065819101 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.128616879457381 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0829058000493267 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle