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Protein Overview: DUG3

General Information:
Name(s) found: DUG3 / YNL191W [SGD]
Description(s) found:
Found 31 descriptions.
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  • Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 357 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: glutathione catabolic process [IMPLink to PubMed article]
    Molecular Function: carbon-nitrogen ligase activity, with glutamine as amido-N-donor [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCRFLIFKGK QPIRLSHLLT RPAHSIINQS FDSRLRLDRR RPMNGDGFGV AYYPLDTELS  60
   61 EDGPCLFKAI TPAWNNQNLS TLAEKTKSDL VFAHVRASTY GVLSETNCHP FTYHSLCFMH 120
  121 NGGISNFKGI KRKLLNHIKD EYLNFIQGST DSECAFALFL DTLDKLGYDP KKQDGDFGNV 180
  181 ALRKAMLRTI DYIRDWTKEA NKDEAHVEPS LLNFAVTDGS TVVVSRYITS KTDEAASLHF 240
  241 SCGSSFVETS PGEYRVERLD RNQDVIMVAS EPLTFERGDW TAVPTNSILT IKKQTILLHP 300
  301 IIDEYYQEDP LYLRSSTLAE SKGLMGSIPL AKAVEKNVPP LEREGRTRPP TAVAHIA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data DUG3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..357] PSI-BLAST 102.39794 "Isomerase domain" of glucosamine 6-phosphate synthase (GLMS); Glucosamine 6-phosphate synthase, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • gamma-glutamyltransferase activity
    		•  2.74011689892782 bayes_pls_golite062009
  • transferase activity, transferring amino-acyl groups
    		•  2.36029325925717 bayes_pls_golite062009
  • peptidase activity
    		•  1.22578220128663 bayes_pls_golite062009
  • catalytic activity
    		•  1.19663085909195 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.19576196677656 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.09683163862369 bayes_pls_golite062009
  • binding
    		•  1.0646751508156 bayes_pls_golite062009
  • hydrolase activity
    		•  1.05106912722792 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.775598918274557 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle