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Protein Overview: NPR1

General Information:
Name(s) found: NPR1 / YNL183C [SGD]
Description(s) found:
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  • gi|6324146|ref|NP_014216.1| Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; Npr1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S63138 probable protein kinase NPR1 (EC 2.7.1.-) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1709340|sp|P22211.2|NPR1_YEAST RecName: Full=Nitrogen permease reactivator protein; AltName: Full=Serine/threonine-protein kinase NPR1 [NCBI NR]
  • gi|1302168|emb|CAA96076.1| NPR1 [Saccharomyces cerevisiae] [NCBI NR]
  • Nitrogen permease reactivator protein OS=Saccharomyces cerevisiae GN=NPR1 PE=1 SV=2 [Swiss-Prot]
  • NPR1 Ser/thr protein kinase [mips]
  • Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation [SGD]
  • NPR1, Chr XIV from 293134-295506, reverse complement [yeast_orfs2]
  • Chr XIV from 293134-295506, reverse complement [yeastorf3.fasta]
  • Chr XIV from 295506-293134, reverse complement [yeastorf5.fasta]
  • (P22211) Nitrogen permease reactivator protein (EC 2.7.1.-) [4932.FASTACCERV.txt]
  • NPR1 SGDID:S0005127, Chr XIV from 295509-293137, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Npr1p [Saccharomyces cerevisiae]gi|1302168|emb|CAA96076.1| NPR1 [Saccharomyces cerevisiae]gi|1709340|sp|P22211|NPR1_YEAST Nitrogen permease reactivator proteingi|2133046|pir||S63138 probable protein kinase NPR1 (EC 2.7.1.-) - yeast (Saccharomyces cere [nrdb_11152004_Chlamydomonas]
  • NPR1 SGDID:S000005127, Chr XIV from 295511-293139, reverse complement, Verified ORF, "Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; Npr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Nitrogen permease reactivator protein [nr-271106-contam.fasta]
  • NPR1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Nitrogen permease reactivator protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NPR1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NPR1 SGDID:S000005127, Chr XIV from 295509-293137, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p" [yeast-030211-contam.fasta]
  • NPR1 SGDID:S000005127, Chr XIV from 295509-293137, Genome Release 64-2-1, reverse complement, Verified ORF, "Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex; NPR1 has a paralog, PRR2, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YNL183C SGDID:S000005127, Chr XIV from 295509-293137, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 790 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Golgi apparatus [IDALink to PubMed article]
    Biological Process: regulation of nitrogen utilization [IMPLink to PubMed article]
    Molecular Function: kinase activity [ISSLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLTRLLQE KRKNETSNSS PRTSADTLTT TPESQSLDLH SRNKSSSHIG SVSNSSSSDR  60
   61 NRANVPVPGS VTTVTQIYSE EDSSSTAGSS LDDRNQFSSS FLNANFAHTA SFYGTSAQSR 120
  121 DRFGSLINDQ GTAGLSSHGG SFAAQNRITS RLSTTSHTSG RAIPSLSSSI PYSVPNSNKD 180
  181 NNSSNSNSSS LSSSWLETYA GGMPNNISAI DSNVISSPKV DSVEPRFVIS KQKLQKASMD 240
  241 SNNANATQSR SISRSGSFSS QLGNFFFSKN SKESSNSNSA GMSFSANSNG PSPNIKNPNV 300
  301 TNGSTPIPKP IRARQSSIYS ASRQPTGSYT DNFYGSPSSV HDHLPPSQSV PRSQHSSIGD 360
  361 LKRFFKKSSN SNLSSNSNNV IPNGSPLSSG IAVPSHSHSS SHFAAGNNSY STSYNGNGDT 420
  421 IYSHSHGGSG IPFSKRYIKT GADLGAGAGG SVKLAQRISD NKIFAVKEFR TKFENESKRD 480
  481 YVKKITSEYC IGTTLNHPNI IETIEIVYEN DRILQVMEYC EYDLFAIVMS NKMSYEEICC 540
  541 CFKQILTGVQ YLHSIGLAHR DLKLDNCVIN EKGIVKLIDF GAAVVFSYPF SKNLVEASGI 600
  601 VGSDPYLAPE VCIFAKYDPR PVDIWSSAII FACMILKKFP WKIPKLRDNS FKLFCSGRDC 660
  661 DSLSSLVTRT PDPPSYDESH STEKKKPESS SNNVSDPNNV NIGPQRLLHS LPEETQHIVG 720
  721 RMIDLAPACR GNIEEIMEDP WIRSIDMCHL VEDGLSFKVV RGEDHHHTQV DQSEAHIAGL 780
  781 EKKKKKQNNQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NPR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..393] deduced N/A No confident structure predictions are available.
    2 View Details [394..519] PSI-BLAST 323.0103 Cyclin-dependent PK, CDK2
    3 View Details [520..601]
    [744..790]    		 PSI-BLAST 323.0103 Cyclin-dependent PK, CDK2
    4 View Details [602..652] PSI-BLAST 323.0103 Cyclin-dependent PK, CDK2
    5 View Details [653..743] PSI-BLAST 323.0103 Cyclin-dependent PK, CDK2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  3.21098426118693 bayes_pls_golite062009
  • protein binding
    		•  1.98649667547181 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  2.89056165975555 bayes_pls_golite062009
  • protein kinase activity
    		•  2.1541160468938 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.10717018320227 bayes_pls_golite062009
  • kinase activity
    		•  1.87492648294538 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.55827408748345 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.55379052459468 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • protein binding
    		•  1.12583111976692 bayes_pls_golite062009
  • transferase activity
    		•  1.02325581375333 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.00700909073980904 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle