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View Structure Prediction Details

Protein: NPR1
Organism: Saccharomyces cerevisiae
Length: 790 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NPR1.

Description E-value Query
Range
Subject
Range
gi|151944357 - gi|151944357|gb|EDN62635.1| nitrogen permease regulator [Saccharomyces cerevisiae YJM789]
gi|4047, gi|227593 - gi|4047|emb|CAA39564.1| nitrogen permease reactivator protein [Saccharomyces cerevisiae], gi|227593|...
0.0 [1..781] [1..781]
gi|238478996, gi... - pir||D96699 hypothetical protein F12B7.13 [imported] - Arabidopsis thaliana, gi|238478996|ref|NP_00...
0.0 [102..781] [19..744]
gi|575365 - gi|575365|emb|CAA56732.1| cdc2-related protein kinase 1 [Plasmodium falciparum]
0.0 [75..758] [19..692]
NTF4_TOBAC - Mitogen-activated protein kinase homolog NTF4 OS=Nicotiana tabacum GN=NTF4 PE=2 SV=1
0.0 [389..790] [12..389]
MMK1_MEDSA - Mitogen-activated protein kinase homolog MMK1 OS=Medicago sativa GN=MMK1 PE=1 SV=1
0.0 [397..790] [14..384]
gi|7649153 - gi|7649153|gb|AAF65766.1|AF242308_1 mitogen-activated protein kinase [Euphorbia esula]
0.0 [394..790] [11..385]
gi|8132287 - gi|8132287|gb|AAF73236.1|AF153061_1 MAP kinase 3 [Pisum sativum]
0.0 [414..790] [15..369]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [402..790] [3..369]

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Predicted Domain #1
Region A:
Residues: [1-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLTRLLQE KRKNETSNSS PRTSADTLTT TPESQSLDLH SRNKSSSHIG SVSNSSSSDR  60
   61 NRANVPVPGS VTTVTQIYSE EDSSSTAGSS LDDRNQFSSS FLNANFAHTA SFYGTSAQSR 120
  121 DRFGSLINDQ GTAGLSSHGG SFAAQNRITS RLSTTSHTSG RAIPSLSSSI PYSVPNSNKD 180
  181 NNSSNSNSSS LSSSWLETYA GGMPNNISAI DSNVISSPKV DSVEPRFVIS KQKLQKASMD 240
  241 SNNANATQSR SISRSGSFSS QLGNFFFSKN SKESSNSNSA GMSFSANSNG PSPNIKNPNV 300
  301 TNGSTPIPKP IRARQSSIYS ASRQPTGSYT DNFYGSPSSV HDHLPPSQSV PRSQHSSIGD 360
  361 LKRFFKKSSN SNLSSNSNNV IPNGSPLSSG IAV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [394-519]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSHSHSSSHF AAGNNSYSTS YNGNGDTIYS HSHGGSGIPF SKRYIKTGAD LGAGAGGSVK  60
   61 LAQRISDNKI FAVKEFRTKF ENESKRDYVK KITSEYCIGT TLNHPNIIET IEIVYENDRI 120
  121 LQVMEY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 323.0103
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 3.21098426118693 bayes_pls_golite062009
protein binding 1.98649667547181 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [520-601]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CEYDLFAIVM SNKMSYEEIC CCFKQILTGV QYLHSIGLAH RDLKLDNCVI NEKGIVKLID  60
   61 FGAAVVFSYP FSKNLVEASG IV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [744-790]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIDMCHLVED GLSFKVVRGE DHHHTQVDQS EAHIAGLEKK KKKQNNQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 323.0103
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.89056165975555 bayes_pls_golite062009
protein kinase activity 2.1541160468938 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.10717018320227 bayes_pls_golite062009
kinase activity 1.87492648294538 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.55827408748345 bayes_pls_golite062009
protein serine/threonine kinase activity 1.55379052459468 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
protein binding 1.12583111976692 bayes_pls_golite062009
transferase activity 1.02325581375333 bayes_pls_golite062009
nucleic acid binding 0.00700909073980904 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [602-652]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSDPYLAPEV CIFAKYDPRP VDIWSSAIIF ACMILKKFPW KIPKLRDNSF K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 323.0103
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [653-743]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFCSGRDCDS LSSLVTRTPD PPSYDESHST EKKKPESSSN NVSDPNNVNI GPQRLLHSLP  60
   61 EETQHIVGRM IDLAPACRGN IEEIMEDPWI R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 323.0103
Match: 1aq1__
Description: Cyclin-dependent PK, CDK2
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle