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Protein Overview: SKO1

General Information:
Name(s) found: SKO1 / YNL167C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 647 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    Molecular Function: RNA polymerase II transcription factor activity [IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEERSRQP STVSTFDLEP NPFEQSFASS KKALSLPGTI SHPSLPKELS RNNSTSTITQ  60
   61 HSQRSTHSLN SIPEENGNST VTDNSNHNDV KKDSPSFLPG QQRPTIISPP ILTPGGSKRL 120
  121 PPLLLSPSIL YQANSTTNPS QNSHSVSVSN SNPSAIGVSS TSGSLYPNSS SPSGTSLIRQ 180
  181 PRNSNVTTSN SGNGFPTNDS QMPGFLLNLS KSGLTPNESN IRTGLTPGIL TQSYNYPVLP 240
  241 SINKNTITGS KNVNKSVTVN GSIENHPHVN IMHPTVNGTP LTPGLSSLLN LPSTGVLANP 300
  301 VFKSTPTTNT TDGTVNNSIS NSNFSPNTST KAAVKMDNPA EFNAIEHSAH NHKENENLTT 360
  361 QIENNDQFNN KTRKRKRRMS STSSTSKASR KNSISRKNSA VTTAPAQKDD VENNKISNNV 420
  421 TLDENEEQER KRKEFLERNR VAASKFRKRK KEYIKKIEND LQFYESEYDD LTQVIGKLCG 480
  481 IIPSSSSNSQ FNVNVSTPSS SSPPSTSLIA LLESSISRSD YSSAMSVLSN MKQLICETNF 540
  541 YRRGGKNPRD DMDGQEDSFN KDTNVVKSEN AGYPSVNSRP IILDKKYSLN SGANISKSNT 600
  601 TTNNVGNSAQ NIINSCYSVT NPLVINANSD THDTNKHDVL STLPHNN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) HHT1, HHT2 SKO1 VAC7

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SKO1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] ORFEUS 11.55 Fibrinogen
    2 View Details [130..135]
    [358..430]    		 ORFEUS 7.75 No description for 1l8mA was found.
    3 View Details [136..208] ORFEUS 7.75 No description for 1l8mA was found.
    4 View Details [209..287] ORFEUS 7.75 No description for 1l8mA was found.
    5 View Details [288..357] ORFEUS 7.75 No description for 1l8mA was found.
    6 View Details [431..553] PSI-BLAST 21.09691 Transcription factor Creb
    7 View Details [554..647] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle