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Protein Overview: APJ1

General Information:
Name(s) found: APJ1 / YNL077W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 528 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: unfolded protein binding [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQNTSLYDS LNVTAAASTS EIKKAYRNAA LKYHPDKNNH TEESKRKFQE ICQAYEILKD  60
   61 NRLRALYDQY GTTDEVLIQE QQAQAQRQQA GPFSSSSNFD TEAMSFPDLS PGDLFAQFFN 120
  121 SSATPSSNGS KSSFNFSFNN SSTPSFSFVN GSGVNNLYSS SAKYNSNDED HHLDRGPDIK 180
  181 HNLKCTLKEL YMGKTAKLGL NRTRICSVCD GHGGLKKCTC KTCKGQGIQT QTRRMGPLVQ 240
  241 SWSQTCADCG GAGVFVKNKD ICQQCQGLGF IKERKILQVT VQPGSCHNQL IVLTGEGDEV 300
  301 ISTKGGGHEK VIPGDVVITI LRLKDPNFQV INYSNLICKK CKIDFMTSLC GGVVYIEGHP 360
  361 SGKLIKLDII PGEILKPGCF KTVEDMGMPK FINGVRSGFG HLYVKFDVTY PERLEPENAK 420
  421 KIQNILANDK YIKAERSTME TADSDCYCDL EKSYDSVEEH VLSSFEAPNL NNEVIEDDDL 480
  481 GDLINERDSR KRNNRRFDES NINNNNETKR NKYSSPVSGF YDHDINGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data APJ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] PSI-BLAST 159.855515 DnaJ chaperone, N-terminal (J) domain
    2 View Details [130..259] PSI-BLAST 56.0103 Cysteine-rich domain of the chaperone protein DnaJ.
    3 View Details [260..457] PSI-BLAST 20.522879 Heat shock protein 40 Sis1
    4 View Details [458..528] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  3.04403163860617 bayes_pls_golite062009
  • binding
    		•  2.63138872417193 bayes_pls_golite062009
  • heat shock protein binding
    		•  2.17994194200939 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.91297632253219 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.6342534817623 bayes_pls_golite062009
  • chaperone binding
    		•  1.61155546076854 bayes_pls_golite062009
  • protein binding
    		•  1.60937254813642 bayes_pls_golite062009
  • DNA binding
    		•  1.55234338199368 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  0.541755903922701 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
    2
    Term Confidence Notes
  • binding
    		•  2.7298921704023 bayes_pls_golite062009
  • protein disulfide isomerase activity
    		•  2.4409950647303 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing S-S bonds
    		•  2.4409950647303 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, interconverting keto- and enol-groups
    		•  2.23398279564144 bayes_pls_golite062009
  • unfolded protein binding
    		•  2.04158808514315 bayes_pls_golite062009
  • protein binding
    		•  1.57926302986794 bayes_pls_golite062009
  • catalytic activity
    		•  0.276917867171685 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle