Protein Overview: DOM34

General Information:
Name(s) found:	DOM34 / YNL001W [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Endoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota [SGD]
Organism:	Saccharomyces cerevisiae
Length:	386 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	meiosis [TAS] translation [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVISLKKDS FNKGGAVITL LPEDKEDLFT VYQIVDKDDE LIFKKKFTSK LDEAGKKKST  60
   61 DLVKLKIKVI SEDFDMKDEY LKYKGVTVTD ESGASNVDIP VGKYLSFTLD YVYPFTIIKQ 120
  121 NFNKFMQKLL NEACNIEYKS DTAAVVLQEG IAHVCLVTSS STILKQKIEY SMPKKKRTTD 180
  181 VLKFDEKTEK FYKAIYSAMK KDLNFDKLKT IILCSPGFYA KILMDKIFQY AEEEHNKKIL 240
  241 DNKGMFFIAH CSTGYLQGIN EVLKNPLYAS KLQDTKYSKE IMVMDEFLLH LNKDDDKAWY 300
  301 GEKEVVKAAE YGAISYLLLT DKVLHSDNIA QREEYLKLMD SVESNGGKAL VLSTLHSLGE 360
  361 ELDQLTGIAC ILKYPLPDLD EDDGEE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	DOM34	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..135]	PSI-BLAST	120.0	Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
2	View Details	[136..275]	PSI-BLAST	120.0	Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
3	View Details	[276..386]	PSI-BLAST	120.0	Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
RNA binding	3.8176240743328	bayes_pls_golite062009
translation release factor activity	3.48975835887408	bayes_pls_golite062009
translation termination factor activity	3.46050614877315	bayes_pls_golite062009
structural constituent of ribosome	2.50763528378297	bayes_pls_golite062009
binding	2.24516466558786	bayes_pls_golite062009
structural molecule activity	2.17996532926344	bayes_pls_golite062009
nucleic acid binding	2.09371417164502	bayes_pls_golite062009
translation regulator activity	1.83257472130927	bayes_pls_golite062009
translation factor activity, nucleic acid binding	1.81472167858216	bayes_pls_golite062009
mRNA binding	1.38466459724533	bayes_pls_golite062009
	1.36644447800624	bayes_pls_golite062009
ribonuclease activity	0.519765773143644	bayes_pls_golite062009
protein binding	0.381324299701367	bayes_pls_golite062009
hydrolase activity	0.341035995293011	bayes_pls_golite062009
catalytic activity	0.264002643439785	bayes_pls_golite062009

2

No functions predicted.

3

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle