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View Structure Prediction Details

Protein: DOM34
Organism: Saccharomyces cerevisiae
Length: 386 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DOM34.

Description E-value Query
Range		 Subject
Range
ERF1_POLMI - Eukaryotic peptide chain release factor subunit 1 OS=Polyandrocarpa misakiensis GN=ERF1 PE=2 SV=1
 0.0 [2..377] [19..418]
gi|220944832, gi... - gi|220954670|gb|ACL89878.1| eRF1-PA [synthetic construct], gi|220944832|gb|ACL84959.1| eRF1-PA [synt...
gi|194118161, gi... - gi|195160369|ref|XP_002021048.1| GL25132 [Drosophila persimilis], gi|194118161|gb|EDW40204.1| GL2513...
eRF1-PC, eRF1-PB... - The gene eukaryotic release factor 1 is referred to in FlyBase by the symbol Dmel\eRF1 (CG5605, FBgn...
 0.0 [2..385] [19..431]
ETF1 - eukaryotic translation termination factor 1
ERF1_MOUSE - Eukaryotic peptide chain release factor subunit 1 OS=Mus musculus GN=Etf1 PE=1 SV=4
ERF1_MESAU - Eukaryotic peptide chain release factor subunit 1 OS=Mesocricetus auratus GN=ETF1 PE=1 SV=3
gi|118097222 - gi|118097222|ref|XP_414511.2| PREDICTED: similar to C11 protein [Gallus gallus]
ERF1_RABIT - Eukaryotic peptide chain release factor subunit 1 OS=Oryctolagus cuniculus GN=ETF1 PE=1 SV=3
gi|114601971, gi... - gi|114601971|ref|XP_001171542.1| PREDICTED: eukaryotic translation termination factor 1 isoform 3 [P...
gi|126290367 - gi|126290367|ref|XP_001368222.1| PREDICTED: similar to C11 protein [Monodelphis domestica]
tr|M3WU44|M3WU44... - Uncharacterized protein OS=Felis catus GN=ETF1 PE=4 SV=1
ERF1_RAT - Eukaryotic peptide chain release factor subunit 1 OS=Rattus norvegicus GN=Etf1 PE=2 SV=3
gi|73970878, gi|... - gi|73978635|ref|XP_531922.2| PREDICTED: similar to eukaryotic translation termination factor 1 (pred...
ENSCJAT00000013296 - null
gi|109078786 - gi|109078786|ref|XP_001113021.1| PREDICTED: similar to eukaryotic translation termination factor 1 (...
ERF1_BOVIN - Eukaryotic peptide chain release factor subunit 1 OS=Bos taurus GN=ETF1 PE=2 SV=3
 0.0 [2..377] [19..418]
ERF1_XENLA - Eukaryotic peptide chain release factor subunit 1 OS=Xenopus laevis GN=etf1 PE=2 SV=1
 0.0 [2..385] [19..425]
gi|15489222 - gi|15489222|gb|AAH13717.1| Eukaryotic translation termination factor 1 [Mus musculus]
 0.0 [2..377] [19..418]
gi|85084324 - gi|85084324|ref|XP_957296.1| eukaryotic peptide chain release factor subunit 1 [Neurospora crassa OR...
gi|28918385, gi|... - gi|32403766|ref|XP_322496.1| EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 (ERF1) (EUKARYOTIC RE...
 0.0 [2..384] [19..430]
gi|158283373, gi... - gi|18250310|gb|AAL17660.1| eukaryotic release factor 1 [Chlamydomonas reinhardtii], gi|159471451|ref...
 0.0 [2..386] [18..425]
ERF1X_ARATH - Eukaryotic peptide chain release factor subunit 1-1 OS=Arabidopsis thaliana GN=ERF1-1 PE=1 SV=2
 0.0 [2..385] [18..429]

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Predicted Domain #1
Region A:
Residues: [1-135] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVISLKKDS FNKGGAVITL LPEDKEDLFT VYQIVDKDDE LIFKKKFTSK LDEAGKKKST  60
   61 DLVKLKIKVI SEDFDMKDEY LKYKGVTVTD ESGASNVDIP VGKYLSFTLD YVYPFTIIKQ 120
  121 NFNKFMQKLL NEACN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 120.0
Match: 1dt9A_
Description: Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 3.8176240743328 bayes_pls_golite062009
translation release factor activity 3.48975835887408 bayes_pls_golite062009
translation termination factor activity 3.46050614877315 bayes_pls_golite062009
structural constituent of ribosome 2.50763528378297 bayes_pls_golite062009
binding 2.24516466558786 bayes_pls_golite062009
structural molecule activity 2.17996532926344 bayes_pls_golite062009
nucleic acid binding 2.09371417164502 bayes_pls_golite062009
translation regulator activity 1.83257472130927 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.81472167858216 bayes_pls_golite062009
mRNA binding 1.38466459724533 bayes_pls_golite062009
1.36644447800624 bayes_pls_golite062009
ribonuclease activity 0.519765773143644 bayes_pls_golite062009
protein binding 0.381324299701367 bayes_pls_golite062009
hydrolase activity 0.341035995293011 bayes_pls_golite062009
catalytic activity 0.264002643439785 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [136-275] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IEYKSDTAAV VLQEGIAHVC LVTSSSTILK QKIEYSMPKK KRTTDVLKFD EKTEKFYKAI  60
   61 YSAMKKDLNF DKLKTIILCS PGFYAKILMD KIFQYAEEEH NKKILDNKGM FFIAHCSTGY 120
  121 LQGINEVLKN PLYASKLQDT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 120.0
Match: 1dt9A_
Description: Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [276-386] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYSKEIMVMD EFLLHLNKDD DKAWYGEKEV VKAAEYGAIS YLLLTDKVLH SDNIAQREEY  60
   61 LKLMDSVESN GGKALVLSTL HSLGEELDQL TGIACILKYP LPDLDEDDGE E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 120.0
Match: 1dt9A_
Description: Middle domain of eukaryotic peptide chain release factor subunit 1, ERF1; C-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1; N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle