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Protein Overview: GPI12

General Information:
Name(s) found: GPI12 / YMR281W [SGD]
Description(s) found:
Found 24 descriptions.
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  • ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 304 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [ISSLink to PubMed article]
    Biological Process: GPI anchor biosynthetic process [ISSLink to PubMed article]
    Molecular Function: N-acetylglucosaminylphosphatidylinositol deacetylase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKMLRRTKVN FSKLLYKITK LAIVLTILYI YFTPKIVSRN NASLQHIFPH KYGDYEINLV  60
   61 IAHPDDEVMF FSPIISQLNS YFPRTVPFNI ICLSKGNAEG LGETRVRELN ESAALLLHNE 120
  121 RAVSVQVMDF QDGMDEIWDI DSITSSLSQK IDIKNHNLNQ IIVTFDSYGV SNHINHKSCY 180
  181 AAVKKLVDDY AQPKTKRNEQ PPHVTALYLR SYKNNIVLKY NSFIWEILKI LYDLISPFRR 240
  241 IIQALPPNTA AEKDKLSLMN THAQYVLAFA TMLNAHESQV VWFRYGWWIF SRFVFVNEFD 300
  301 VYTY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ERI1 GPI11 GPI12

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBC7 GPI12 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GPI12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..250] MSA 10.064982 View MSA. No confident structure predictions are available.
    2 View Details [251..304] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle