YRC Public Data Repository - Protein Structure Prediction

Protein:	GPI12
Organism:	Saccharomyces cerevisiae
Length:	304 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GPI12.

Description	E-value	Query Range	Subject Range
gi\|190408507 - gi\|190408507\|gb\|EDV11772.1\| N-acetylglucosaminylphosphatidylinositol de-N-acetylase [Saccharomyces c... gi\|207342063 - gi\|207342063\|gb\|EDZ69942.1\| YMR281Wp-like protein [Saccharomyces cerevisiae AWRI1631] GPI12 - ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembl... GPI12_YEAST - N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase OS=Saccharomyces cerevisiae (strain ATCC 20...	4.0E-86	[1..304]	[1..304]
gpi12 - pig-L GPI12_SCHPO - Probable N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase OS=Schizosaccharomyces pombe (stra...	6.0E-56	[23..299]	[2..244]
PIGL_RAT - N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase OS=Rattus norvegicus GN=Pigl PE=2 SV=1	1.0E-53	[21..301]	[11..251]
gi\|255095852 - gi\|255095852\|ref\|ZP_05325330.1\| mycothiol conjugate amidase [Mycobacterium tuberculosis KZN 605] gi\|254814875 - gi\|254814875\|ref\|ZP_05219876.1\| mycothiol conjugate amidase [Mycobacterium tuberculosis KZN 4207] gi\|254550074 - gi\|254550074\|ref\|ZP_05140521.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis '98-R604... gi\|253321385, gi... - gi\|253799882\|ref\|YP_003032883.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis KZN 143... gi\|134149507, gi... - gi\|254363993\|ref\|ZP_04980039.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis str. Haa... gi\|148505019, gi... - gi\|167967357\|ref\|ZP_02549634.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis H37Ra], ... gi\|31617861, gi\|... - gi\|31792273\|ref\|NP_854766.1\| Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase) [Mycoba... MCA_MYCTU - Mycothiol S-conjugate amidase OS=Mycobacterium tuberculosis GN=mca PE=1 SV=1 gi\|123214634, gi... - gi\|76785142\|ref\|ZP_00772315.1\| COG2120: Uncharacterized proteins, LmbE homologs [Mycobacterium tuber... gi\|81254994, gi\|... - gi\|81254994\|ref\|ZP_00879488.1\| COG2120: Uncharacterized proteins, LmbE homologs [Mycobacterium tuber... gi\|215402905 - gi\|215402905\|ref\|ZP_03415086.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis 02_1987] gi\|215410695 - gi\|215410695\|ref\|ZP_03419503.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis 94_M4241... gi\|215426371 - gi\|215426371\|ref\|ZP_03424290.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis T92] gi\|215429948 - gi\|215429948\|ref\|ZP_03427867.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis EAS054] MCA_MYCTO - Mycothiol S-conjugate amidase OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) GN=mca PE=3 ... gi\|121637011, gi... - gi\|121637011\|ref\|YP_977234.1\| Mycothiol conjugate amidase Mca [Mycobacterium bovis BCG str. Pasteur ... gi\|215445237 - gi\|215445237\|ref\|ZP_03431989.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis T85] MCA_MYCTU - Mycothiol S-conjugate amidase OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=mca PE=1 ... gi\|218752762 - gi\|218752762\|ref\|ZP_03531558.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis GM 1503] gi\|219556959 - gi\|219556959\|ref\|ZP_03536035.1\| mycothiol conjugate amidase mca [Mycobacterium tuberculosis T17] gi\|224772597, gi... - gi\|224989484\|ref\|YP_002644171.1\| mycothiol conjugate amidase [Mycobacterium bovis BCG str. Tokyo 172...	2.0E-49	[52..287]	[1..261]
PIGL - phosphatidylinositol glycan anchor biosynthesis, class L	2.0E-49	[21..299]	[11..249]
MSHB_MYCLB - 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase OS=Mycobacterium leprae (str... MSHB_MYCLE - 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase OS=Mycobacterium leprae (str... MSHB_MYCLE - 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase OS=Mycobacterium leprae GN=m...	6.0E-48	[56..281]	[6..253]
gi\|19170945, gi\|... - gi\|19173356\|ref\|NP_597159.1\| hypothetical protein ECU08_0300 [Encephalitozoon cuniculi GB-M1], gi\|19... gi\|19173356 - gi\|19173356\|ref\|NP_597159.1\| hypothetical protein ECU08_0300 [Encephalitozoon cuniculi GB-M1]	9.0E-43	[3..301]	[7..244]
gi\|18976726, gi\|... - gi\|18976726\|ref\|NP_578083.1\| hypothetical protein PF0354 [Pyrococcus furiosus DSM 3638], gi\|18892310...	8.0E-40	[32..248]	[12..230]
gi\|7518675 - pir\|\|F71162 hypothetical protein PH0499 - Pyrococcus horikoshii gi\|3256904, gi\|1... - gi\|3256904\|dbj\|BAA29587.1\| 272aa long hypothetical protein [Pyrococcus horikoshii OT3], gi\|14590405\|...	3.0E-39	[32..248]	[16..235]

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Predicted Domain #1

Region A:
Residues: [1-250]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKMLRRTKVN FSKLLYKITK LAIVLTILYI YFTPKIVSRN NASLQHIFPH KYGDYEINLV  60
   61 IAHPDDEVMF FSPIISQLNS YFPRTVPFNI ICLSKGNAEG LGETRVRELN ESAALLLHNE 120
  121 RAVSVQVMDF QDGMDEIWDI DSITSSLSQK IDIKNHNLNQ IIVTFDSYGV SNHINHKSCY 180
  181 AAVKKLVDDY AQPKTKRNEQ PPHVTALYLR SYKNNIVLKY NSFIWEILKI LYDLISPFRR 240
  241 IIQALPPNTA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [251-304]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AEKDKLSLMN THAQYVLAFA TMLNAHESQV VWFRYGWWIF SRFVFVNEFD VYTY

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits