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Protein Overview: DDR48

General Information:
Name(s) found: DDR48 / YMR173W [SGD]
Description(s) found:
Found 23 descriptions.
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  • DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 430 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: DNA repair [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: ATPase activity [IDALink to PubMed article]
    GTPase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLFDKVKQF ANSNNNNNDS GNNNQGDYVT KAENMIGEDR VNQFKSKIGE DRFDKMESKV  60
   61 RQQFSNTSIN DNDSNNNDSY GSNNNDSYGS NNNDSYGSNN NDSYGSNNND SYGSNNDDSY 120
  121 GSSNKKKSSY GSNNDDSYGS SNNNDSYGSN NNDSYGSNNN DSYGSNNDDS YGSSNKNKSS 180
  181 YGSNNDDSYG SNNDDSYGSS NKKKSSYGSS NNDSYGSNND DSYGSNNNDS YGSNNDDSYG 240
  241 SSNKKKSSYG SNNDDSYGSS NNNDSYGSNN DDSYGSSNKN KSSYGSSSND DSYGSSNNDD 300
  301 SYGSSNKKKS SYGSNNDDSY GSNNDDSYGS SNKKKSSYGS SNNDSYGSNN DDSYGSSNKK 360
  361 KSSYGSNNDD SYGSSNNNDS YGSNNDDSYG SSNRNKNSYG SSNYGSSNND DSYGSSNRGG 420
  421 RNQYGGDDDY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) ATP16 DDR48 FIT1 RPP1A YMR118C
    View Details Krogan NJ, et al. (2006) DDR48 FCP1 IDP1 YMR118C ZEO1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DDR48 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..203] PSI-BLAST 23.522879 Metalloprotease
    2 View Details [204..430] PSI-BLAST 23.522879 Metalloprotease


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle