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Protein Overview: PAH1

General Information:
Name(s) found: PAH1 / YMR165C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Mg<sup>2+</sup>-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and P<sub>i</sub>, responsible for de novo lipid synthesis; homologous to mammalian lipin 1 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 862 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: lipid biosynthetic process [IMPLink to PubMed article]
    plasmid maintenance [IMPLink to PubMed article]
    aerobic respiration [IMPLink to PubMed article]
    Molecular Function: phosphatidate phosphatase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQYVGRALGS VSKTWSSINP ATLSGAIDVI VVEHPDGRLS CSPFHVRFGK FQILKPSQKK  60
   61 VQVFINEKLS NMPMKLSDSG EAYFVFEMGD QVTDVPDELL VSPVMSATSS PPQSPETSIL 120
  121 EGGTEGEGEG ENENKKKEKK VLEEPDFLDI NDTGDSGSKN SETTGSLSPT ESSTTTPPDS 180
  181 VEERKLVEQR TKNFQQKLNK KLTEIHIPSK LDNNGDLLLD TEGYKPNKNM MHDTDIQLKQ 240
  241 LLKDEFGNDS DISSFIKEDK NGNIKIVNPY EHLTDLSPPG TPPTMATSGS VLGLDAMESG 300
  301 STLNSLSSSP SGSDTEDETS FSKEQSSKSE KTSKKGTAGS GETEKRYIRT IRLTNDQLKC 360
  361 LNLTYGENDL KFSVDHGKAI VTSKLFVWRW DVPIVISDID GTITKSDALG HVLAMIGKDW 420
  421 THLGVAKLFS EISRNGYNIL YLTARSAGQA DSTRSYLRSI EQNGSKLPNG PVILSPDRTM 480
  481 AALRREVILK KPEVFKIACL NDIRSLYFED SDNEVDTEEK STPFFAGFGN RITDALSYRT 540
  541 VGIPSSRIFT INTEGEVHME LLELAGYRSS YIHINELVDH FFPPVSLDSV DLRTNTSMVP 600
  601 GSPPNRTLDN FDSEITSGRK TLFRGNQEEK FTDVNFWRDP LVDIDNLSDI SNDDSDNIDE 660
  661 DTDVSQQSNI SRNRANSVKT AKVTKAPQRN VSGSTNNNEV LAASSDVENA SDLVSSHSSS 720
  721 GSTPNKSTMS KGDIGKQIYL ELGSPLASPK LRYLDDMDDE DSNYNRTKSR RASSAAATSI 780
  781 DKEFKKLSVS KAGAPTRIVS KINVSNDVHS LGNSDTESRR EQSVNETGRN QLPHNSMDDK 840
  841 DLDSRVSDEF DDDEFDEDEF ED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data PAH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..156] deduced N/A No confident structure predictions are available.
    2 View Details [157..654] MSA 4.01789 View MSA. No confident structure predictions are available.
    3 View Details [655..862] deduced N/A No confident structure predictions are available.
    4 View Details [657..862] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle