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Protein Overview: ASI1

General Information:
Name(s) found: ASI1 / YMR119W [SGD]
Description(s) found:
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  • gi|6323766|ref|NP_013837.1| Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals; Asi1p [ [NCBI NR]
  • pir||S54581 probable membrane protein YMR119w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1730603|sp|P54074.1|ASI1_YEAST RecName: Full=Protein ASI1; AltName: Full=Amino acid sensor-independent protein 1 [NCBI NR]
  • (P54074) Uncharacterized protein YMR119W [Swiss-Prot]
  • Protein ASI1 OS=Saccharomyces cerevisiae GN=ASI1 PE=1 SV=1 [Swiss-Prot]
  • ASI1 Putative integral membrane E3 ubiquitin ligase [mips]
  • Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals [SGD]
  • YMR119W, Chr XIII from 505332-507206 [yeast_orfs2]
  • Chr XIII from 505332-507206 [yeastorf3.fasta]
  • (P54074) Hypothetical 71.4 kDa protein in ILV2-ADE17 intergenic region [4932.FASTACCERV.txt]
  • ASI1 SGDID:S0004725, Chr XIII from 505332-507206, Verified ORF [yeastflysequest.fasta]
  • Asi1p [Saccharomyces cerevisiae]gi|1730603|sp|P54074|YM08_YEAST Hypothetical 71.4 kDa protein in ILV2-ADE17 intergenic regiongi|2132724|pir||S54581 probable membrane protein YMR119w - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • ASI1 SGDID:S000004725, Chr XIII from 505332-507206, Verified ORF, "Putative integral membrane E3 ubiquitin ligase; genetic interactions suggest a role in negative regulation of amino acid uptake" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ASI1 SGDID:S000004725, Chr XIII from 505332-507206, Verified ORF, "Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in t [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Protein ASI1 (Amino acid sensor-independent protein 1) [nr-271106-contam.fasta]
  • Putative integral membrane E3 ubiquitin ligase; genetic interactions suggest a role in negative regulation of amino acid uptake; Asi1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ASI1 SGDID:S000004725, Chr XIII from 505332-507206, Verified ORF, "Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Protein ASI1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ASI1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ASI1 SGDID:S000004725, Chr XIII from 505333-507207, Genome Release 64-1-1, Verified ORF, "Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals" [yeast-030211-contam.fasta]
  • ASI1 SGDID:S000004725, Chr XIII from 505333-507207, Genome Release 64-2-1, Verified ORF, "Subunit of the nuclear inner membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by targeting latent unprocessed forms of Stp1p and Stp2p and maintains the repressed state of gene expression in the absence of inducing amino acids; ASI1 has a paralog, ASI3, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YMR119W SGDID:S000004725, Chr XIII from 505333-507207, Genome Release 64-1-1, Verified ORF, "Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 624 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IGILink to PubMed article][ISSLink to PubMed article]
    nuclear inner membrane [IDALink to PubMed article]
    Biological Process: ubiquitin-dependent protein catabolic process [IGILink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSSTSSENV FINSFSYLNQ TSQAVISGNS TFANVINFPY RLGLSFIGAV NLQYEQTVKS  60
   61 EEIPPTLRSV FDTIGFFFSP YAIFCFVIAI VLNRFVVFYA VLNNGSRRTL PLWLSNVFHV 120
  121 SAVVVLAMVS LGPLTLGKDF KILGDPAFAQ EKFLLNIFYA FAYSYCVETI FTIMRNSSPL 180
  181 EGTDYSLFEL SIQFYTMTNN NTKFLDSPDY IIDCSMAILS RILIHLVEIF RLRNYRLLFS 240
  241 TIMNLCHICY LGIRVKQGGW KSLPFSVKFR HFPKLFSVSI ICLSLLIFKL SCLIRWDPFG 300
  301 KSRNSCELLQ FYPLSRNWKK YLNYTGEEDF SAMATKFALL LCSGTELMEK GIRREFPAIN 360
  361 IPDNVNEKFF ISGYLNELSK PYKENTSISF PKKNSSILKQ RFFLMFPKSI IWIMKKLVGQ 420
  421 VFFGFRDNKD EDIPDNDPSK MLKITKTNSL NNSAGHKEDI ELELLNTSDD EYSEDYEPSE 480
  481 VESLGDSDEE NLEEDSLIFN ETRDALLDLF SSEDNEVHTD YNWIMSTSRI LQQKLLSDKT 540
  541 LTRASILDTK LSEVDETFGT ESDFDLSCAV CKVNERNTVL WPCRCFAICE DCRISLGLRG 600
  601 FSTCVCCRSK VHGYCKVHPV SDSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ASI1 ASI2 ASI3 HRD1 SSM4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ASI1 and NIC96 Huh WK, et al. (2003)
    View Data ASI1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..296] deduced N/A No confident structure predictions are available.
    2 View Details [297..565] PSI-BLAST 16.09691 Heavy meromyosin subfragment
    3 View Details [566..624] PSI-BLAST 13.045757 Cbl; N-terminal domain of cbl (N-cbl); CBL
    4 View Details [560..624] PSI-BLAST 14.522879 Cbl; N-terminal domain of cbl (N-cbl); CBL


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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