Protein Overview: MVP1

General Information:
Name(s) found:	MVP1 / YMR004W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|728651\|emb\|CAA88519.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|6323646\|ref\|NP_013717.1\| Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; Mvp1p [Saccharomyces cerevisia [NCBI NR] gi\|1709190\|sp\|P40959.2\|MVP1_YEAST RecName: Full=Sorting nexin MVP1 [NCBI NR] pir\|\|S53033 MVP1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] Sorting nexin MVP1 OS=Saccharomyces cerevisiae GN=MVP1 PE=1 SV=2 [Swiss-Prot] MVP1 Protein required for vacuolar protein sorting [mips] Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole [SGD] MVP1, Chr XIII from 274017-275552 [yeast_orfs2] Chr XIII from 274017-275552 [yeastorf3.fasta] (P40959) Sorting nexin MVP1 [4932.FASTACCERV.txt] MVP1 SGDID:S0004606, Chr XIII from 274017-275552, Verified ORF [yeastflysequest.fasta] Mvp1p [Saccharomyces cerevisiae]gi\|728651\|emb\|CAA88519.1\| unknown [Saccharomyces cerevisiae]gi\|1709190\|sp\|P40959\|MVP1_YEAST Sorting nexin MVP1gi\|1078552\|pir\|\|S53033 MVP1 protein - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] MVP1 SGDID:S000004606, Chr XIII from 274017-275552, Verified ORF, "Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; Mvp1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Sorting nexin MVP1 [nr-271106-contam.fasta] MVP1 SGDID:S000004606, Chr XIII from 274017-275552, Verified ORF, "Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Sorting nexin MVP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MVP1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MVP1 SGDID:S000004606, Chr XIII from 274017-275552, Genome Release 64-1-1, Verified ORF, "Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole" [yeast-030211-contam.fasta] MVP1 SGDID:S000004606, Chr XIII from 274017-275552, Genome Release 64-2-1, Verified ORF, "Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with "foot domain" of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress" [20141208_orf_trans.fasta] TR8060\|c0_g1_i1\|g.5691 ORF TR8060\|c0_g1_i1\|g.5691 TR8060\|c0_g1_i1\|m.5691 type:complete len:512 (+) TR8060\|c0_g1_i1:119-1654(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YMR004W SGDID:S000004606, Chr XIII from 274017-275552, Genome Release 64-1-1, Verified ORF, "Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_4433\|g.3239 ORF asmbl_4433\|g.3239 asmbl_4433\|m.3239 type:complete len:512 (+) asmbl_4433:126-1661(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_4433\|g.2672 ORF ID=asmbl_4433\|g.2672 ID=asmbl_4433\|m.2672 type:complete len:512 (+) ID=asmbl_4433:126-1661(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	511 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	protein targeting to vacuole [IMP]
Molecular Function:	phosphatidylinositol-3-phosphate binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNYEGSDPW NTSSNAWTKD DDHVVSTTNS EPSLNGISGE FNTLNFSTPL DTNEEDTGFL  60
   61 PTNDVLEESI WDDSRNPLGA TGMSQTPNIA ANETVIDKND ARDQNIEESE ADLLDWTNNV 120
  121 RKTYRPLDAD IIIIEEIPER EGLLFKHANY LVKHLIALPS TSPSEERTVV RRYSDFLWLR 180
  181 EILLKRYPFR MIPELPPKRI GSQNADQLFL KKRRIGLSRF INLVMKHPKL SNDDLVLTFL 240
  241 TVRTDLTSWR KQATYDTSNE FADKKISQEF MKMWKKEFAE QWNQAASCID TSMELWYRIT 300
  301 LLLERHEKRI MQMVHERNFF ETLVDNFSEV TPKLYPVQQN DTILDINNNL SIIKKHLETT 360
  361 SSICKQETEE ISGTLSPKFK IFTDILLSLR SLFERYKIMA ANNVVELQRH VELNKEKLES 420
  421 MKGKPDVSGA EYDRIKKIIQ KDRRSIIEQS NRAWLIRQCI LEEFTIFQET QFLITRAFQD 480
  481 WAKLNSNHAG LKLNEWEKLV TSIMDMPISR E

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		MVP1 SNX4

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MVP1	YLR358C	2	Unpublished Fields Lab Data
View Screen	MVP1	FUS2	2	Unpublished Fields Lab Data
View Screen	SST2	MVP1	2	Unpublished Fields Lab Data
View Screen	MVP1	SRB7	2	Unpublished Fields Lab Data
View Screen	MVP1	PAN1	2	Unpublished Fields Lab Data
View Screen	MVP1	NKP2	2	Unpublished Fields Lab Data
View Screen	MVP1	YNL086W	2	Unpublished Fields Lab Data
View Screen	MVP1	YDL211C	2	Unpublished Fields Lab Data
View Screen	MVP1	URH1	2	Unpublished Fields Lab Data
View Screen	MVP1	SNA3	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MVP1	Huh WK, et al. (2003)
View Data	MVP1 and SNF7	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..84]	deduced	N/A	No confident structure predictions are available.
2	View Details	[85..243]	PSI-BLAST	14.154902	p40phox NADPH oxidase
3	View Details	[244..307] [431..511]	PSI-BLAST	4.39794	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain
4	View Details	[308..430]	PSI-BLAST	4.39794	Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain; Interferon-induced guanylate-binding protein 1 (GBP1), N-terminal domain

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2