Protein Overview: AMD1

General Information:
Name(s) found:	AMD1 / YML035C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6323606\|ref\|NP_013677.1\| AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools; Amd1p [Saccharomyces cerevisiae] [NCBI NR] gi\|575684\|emb\|CAA86620.1\| AMD1 [Saccharomyces cerevisiae] [NCBI NR] gi\|1351916\|sp\|P15274.2\|AMPD_YEAST RecName: Full=AMP deaminase; AltName: Full=Myoadenylate deaminase [NCBI NR] pir\|\|S49744 AMP deaminase (EC 3.5.4.6) - yeast (Saccharomyces cerevisiae) [NCBI NR] AMP deaminase OS=Saccharomyces cerevisiae GN=AMD1 PE=1 SV=2 [Swiss-Prot] (P15274) AMP deaminase (EC 3.5.4.6) (Myoadenylate deaminase) [Swiss-Prot] AMD1 AMP deaminase [mips] AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools [SGD] AMD1, Chr XIII from 206428-208860, reverse complement [yeast_orfs2] Chr XIII from 206428-208860, reverse complement [yeastorf3.fasta] Chr XIII from 208860-206428, reverse complement [yeastorf5.fasta] AMD1 SGDID:S0004498, Chr XIII from 208860-206428, reverse complement, Verified ORF [yeastflysequest.fasta] AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools [Saccharomyces cerevisiae]gi\|575684\|emb\|CAA86620.1\| AMD1 [Saccharomyces cerevisiae]gi [nrdb_11152004_Chlamydomonas] AMD1 SGDID:S000004498, Chr XIII from 208860-206428, reverse complement, Verified ORF, "AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] AMP deaminase (Myoadenylate deaminase) [nr-271106-contam.fasta] AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools; Amd1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] AMD1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] AMP deaminase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AMD1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] AMD1 SGDID:S000004498, Chr XIII from 208860-206428, Genome Release 64-1-1, reverse complement, Verified ORF, "AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools" [yeast-030211-contam.fasta] AMD1 SGDID:S000004498, Chr XIII from 208860-206428, Genome Release 64-2-1, reverse complement, Verified ORF, "AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools" [20141208_orf_trans.fasta] TR1336\|c0_g1_i1\|g.1026 ORF TR1336\|c0_g1_i1\|g.1026 TR1336\|c0_g1_i1\|m.1026 type:complete len:811 (+) TR1336\|c0_g1_i1:179-2611(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YML035C SGDID:S000004498, Chr XIII from 208860-206428, Genome Release 64-1-1, reverse complement, Verified ORF, "AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_4112\|g.2655 ORF ID=asmbl_4112\|g.2655 ID=asmbl_4112\|m.2655 type:complete len:811 (+) ID=asmbl_4112:201-2633(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	810 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	purine nucleotide metabolic process [IC]
Molecular Function:	AMP deaminase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNQATQRLN DLSLEPAPSH DEQDGSGLVI DIDQRKIGDE QAGVVVDDET PPLEQQDSHE  60
   61 SLAADSRNAN FSYHENQQLL ENGTKQLALD EHDSHSAILE QPSHSTNCSS SNIAAMNKGH 120
  121 DSADHASQNS GGKPRTLSAS AQHILPETLK SFAGAPVVNK QVRTSASYKM GMLADDASQQ 180
  181 FLDDPSSELI DLYSKVAECR NLRAKYQTIS VQNDDQNPKN KPGWVVYPPP PKPSYNSDTK 240
  241 TVVPVTNKPD AEVFDFTKCE IPGEDPDWEF TLNDDDSYVV HRSGKTDELI AQIPTLRDYY 300
  301 LDLEKMISIS SDGPAKSFAY RRLQYLEARW NLYYLLNEYQ ETSVSKRNPH RDFYNVRKVD 360
  361 THVHHSACMN QKHLLRFIKH KLRHSKDEKV IFRDGKLLTL DEVFRSLHLT GYDLSIDTLD 420
  421 MHAHKDTFHR FDKFNLKYNP IGESRLREIF LKTNNYIKGT YLADITKQVI FDLENSKYQN 480
  481 CEYRISVYGR SLDEWDKLAS WVIDNKVISH NVRWLVQIPR LYDIYKKTGI VQSFQDICKN 540
  541 LFQPLFEVTK NPQSHPKLHV FLQRVIGFDS VDDESKVDRR FHRKYPKPSL WEAPQNPPYS 600
  601 YYLYYLYSNV ASLNQWRAKR GFNTLVLRPH CGEAGDPEHL VSAYLLAHGI SHGILLRKVP 660
  661 FVQYLYYLDQ VGIAMSPLSN NALFLTYDKN PFPRYFKRGL NVSLSTDDPL QFSYTREPLI 720
  721 EEYSVAAQIY KLSNVDMCEL ARNSVLQSGW EAQIKKHWIG KDFDKSGVEG NDVVRTNVPD 780
  781 IRINYRYDTL STELELVNHF ANFKRTIEEK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		AMD1 YJL070C
View Details	Krogan NJ, et al. (2006)		AMD1 RRB1 YJL070C

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	APC5	AMD1	1	Unpublished Fields Lab Data
View Screen	LSM8	AMD1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	AMD1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..240]	MSA	1.021976	View MSA. No confident structure predictions are available.
2	View Details	[241..293]	deduced	N/A	Confident ab initio structure predictions are available.
3	View Details	[294..562]	Pfam	35.468521	Adenosine/AMP deaminase No confident structure predictions are available.
4	View Details	[563..810]	PSI-BLAST	43.0	No description for 1m7mA_ was found.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
catalytic activity	1.70199291046899	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.12925526582667	bayes_pls_golite062009
transcription regulator activity	0.867179877821333	bayes_pls_golite062009
nucleic acid binding	0.784495708118775	bayes_pls_golite062009
DNA binding	0.58985393219841	bayes_pls_golite062009
binding	0.568044210518453	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	0.248802326836448	bayes_pls_golite062009
hydrolase activity	0.24275130580417	bayes_pls_golite062009
dihydroorotase activity	0.203044795244555	bayes_pls_golite062009
deaminase activity	0.18698811376434	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	0.0954028693917728	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2