Protein Overview: GAB1

General Information:
Name(s) found:	GAB1 / YLR459W [SGD]
Description(s) found: Found 27 descriptions. SHOW ALL	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI [SGD]
Organism:	Saccharomyces cerevisiae
Length:	394 amino acids
Gene Ontology:
Cellular Component:	GPI-anchor transamidase complex [IMP][IPI]
Biological Process:	attachment of GPI anchor to protein [ISS]
Molecular Function:	GPI-anchor transamidase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDSTALKVAL GCIAIRLAVN SLFPSLQQQL DQSVEFSTPV TSFRSLQEGI YLLRNNIQVY  60
   61 NHGVVHHPPI LIFFLSLFNS DRLISLIYAL IDGLIAYQLT EVTKAFKNLK LKVWLPGLLY 120
  121 AVNPLTLLSC ISRSSIIFTN FAISSSLYCI LAEGNVLLSS VMISISGYLS VYPILLLIPL 180
  181 LGMLKSWRQR ILSAIVSILS LLILLLFSYS ILGSQSWSFL TQVYGSIITF EKVFPNLGLW 240
  241 WYFFIEMFDT FIPFFKAVFN IFIAVFITPF TLRYHKQPFY AFILCIGWIV LTKPYPSLGD 300
  301 AGFFFSFLPF FTPLFGYLRY PIISALLFLH AIVLAPIFYH LWVVLGSGNS NFFYAISLVY 360
  361 ALAIASILVD LNWAMLRIEY DNGIPNFKLK VTQI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		ERI1 GAA1 GAB1 GPI11 GPI16 GPI17 GPI8

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NAF1	GAB1	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..127]	MSA	1.017982	View MSA. No confident structure predictions are available.
2	View Details	[128..188]	deduced	N/A	No confident structure predictions are available.
3	View Details	[189..319]	MSA	2.018977	View MSA. No confident structure predictions are available.
4	View Details	[320..394]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2