Protein Overview: MAP1

General Information:
Name(s) found:	MAP1 / YLR244C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|975723\|gb\|AAA75193.1\| methionine aminopeptidase I [NCBI NR] gi\|662342\|gb\|AAB67398.1\| Map1p: methionine aminopeptidase [Saccharomyces cerevisiae] [NCBI NR] gi\|6323273\|ref\|NP_013345.1\| Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; Map1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S59390 methionyl aminopeptidase (EC 3.4.11.18) MAP1 precursor - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1351928\|sp\|Q01662.2\|AMPM1_YEAST RecName: Full=Methionine aminopeptidase 1; Short=MetAP 1; Short=MAP 1; AltName: Full=Peptidase M 1; Flags: Precursor [NCBI NR] Methionine aminopeptidase 1 OS=Saccharomyces cerevisiae GN=MAP1 PE=1 SV=2 [Swiss-Prot] (Q01662) Methionine aminopeptidase 1 precursor (EC 3.4.11.18) (MetAP 1) (MAP 1) (Peptidase M 1) [Swiss-Prot] MAP1 Methionine aminopeptidase, isoform 1 [mips] Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p [SGD] MAP1, Chr XII from 625168-626331, reverse complement [yeast_orfs2] Chr XII from 625168-626331, reverse complement [yeastorf3.fasta] Chr XII from 626331-625168, reverse complement [yeastorf5.fasta] MAP1 SGDID:S0004234, Chr XII from 626333-625170, reverse complement, Verified ORF [yeastflysequest.fasta] Map1p [Saccharomyces cerevisiae]gi\|662342\|gb\|AAB67398.1\| Map1p: methionine aminopeptidase [Saccharomyces cerevisiae]gi\|1363808\|pir\|\|S59390 methionyl aminopeptidase (EC 3.4.11.18) MAP1 precursor - yeast (Saccharomyces cerevisiae)gi\|975723\|gb\|AAA75193.1\| [nrdb_11152004_Chlamydomonas] MAP1 SGDID:S000004234, Chr XII from 626333-625170, reverse complement, Verified ORF, "Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Map1p: methionine aminopeptidase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] methionine aminopeptidase I [nr-271106-contam.fasta] Methionine aminopeptidase 1 precursor (MetAP 1) (MAP 1) (Peptidase M 1) [nr-271106-contam.fasta] Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; Map1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Methionine aminopeptidase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAP1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MAP1 SGDID:S000004234, Chr XII from 626331-625168, Genome Release 64-1-1, reverse complement, Verified ORF, "Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p" [yeast-030211-contam.fasta] MAP1 SGDID:S000004234, Chr XII from 626331-625168, Genome Release 64-2-1, reverse complement, Verified ORF, "Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p" [20141208_orf_trans.fasta] TR6314\|c0_g1_i1\|g.4462 ORF TR6314\|c0_g1_i1\|g.4462 TR6314\|c0_g1_i1\|m.4462 type:complete len:388 (+) TR6314\|c0_g1_i1:672-1835(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR175\|c0_g1_i1\|g.154 ORF TR175\|c0_g1_i1\|g.154 TR175\|c0_g1_i1\|m.154 type:complete len:388 (+) TR175\|c0_g1_i1:679-1842(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YLR244C SGDID:S000004234, Chr XII from 626331-625168, Genome Release 64-1-1, reverse complement, Verified ORF, "Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_7148\|g.5144 ORF asmbl_7148\|g.5144 asmbl_7148\|m.5144 type:complete len:388 (+) asmbl_7148:652-1815(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_7651\|g.5643 ORF asmbl_7651\|g.5643 asmbl_7651\|m.5643 type:complete len:388 (+) asmbl_7651:670-1833(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_7147\|g.4534 ORF ID=asmbl_7147\|g.4534 ID=asmbl_7147\|m.4534 type:complete len:388 (+) ID=asmbl_7147:653-1816(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_7431\|g.4600 ORF ID=asmbl_7431\|g.4600 ID=asmbl_7431\|m.4600 type:complete len:388 (+) ID=asmbl_7431:671-1834(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	387 amino acids
Gene Ontology:
Cellular Component:	cytosolic ribosome [IDA]
Biological Process:	proteolysis [IDA]
Molecular Function:	methionyl aminopeptidase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTATTTVTT SDQASHPTKI YCSGLQCGRE TSSQMKCPVC LKQGIVSIFC DTSCYENNYK  60
   61 AHKALHNAKD GLEGAYDPFP KFKYSGKVKA SYPLTPRRYV PEDIPKPDWA ANGLPVSEQR 120
  121 NDRLNNIPIY KKDQIKKIRK ACMLGREVLD IAAAHVRPGI TTDELDEIVH NETIKRGAYP 180
  181 SPLNYYNFPK SLCTSVNEVI CHGVPDKTVL KEGDIVNLDV SLYYQGYHAD LNETYYVGEN 240
  241 ISKEALNTTE TSRECLKLAI KMCKPGTTFQ ELGDHIEKHA TENKCSVVRT YCGHGVGEFF 300
  301 HCSPNIPHYA KNRTPGVMKP GMVFTIEPMI NEGTWKDMTW PDDWTSTTQD GKLSAQFEHT 360
  361 LLVTEHGVEI LTARNKKSPG GPRQRIK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		MAP1 RKM3
View Details	Krogan NJ, et al. (2006)		MAP1 RKM3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MEC3	MAP1	1	Unpublished Fields Lab Data
View Screen	TEM1	MAP1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MAP1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..115]	deduced	N/A	No confident structure predictions are available.
2	View Details	[116..387]	PSI-BLAST	651.68867	Methionine aminopeptidase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2