Protein Overview: THI7

General Information:
Name(s) found:	THI7 / YLR237W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6323266\|ref\|NP_013338.1\| Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia; Thi7p [Saccharomyces c [NCBI NR] gi\|609365\|gb\|AAB67405.1\| Thi7p: thiamine transporter [Saccharomyces cerevisiae] [NCBI NR] gi\|2492817\|sp\|Q05998.1\|THI7_YEAST RecName: Full=Thiamine transporter [NCBI NR] gi\|1871134\|dbj\|BAA09504.1\| thiamin transport protein [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S51456 probable membrane protein YLR237w - yeast (Saccharomyces cerevisiae) [NCBI NR] Thiamine transporter OS=Saccharomyces cerevisiae GN=THI7 PE=1 SV=1 [Swiss-Prot] THI7 Thiamine permase [mips] Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia [SGD] THI7, Chr XII from 612367-614163 [yeast_orfs2] Chr XII from 612367-614163 [yeastorf3.fasta] (Q05998) Thiamine transporter [4932.FASTACCERV.txt] THI7 SGDID:S0004227, Chr XII from 612369-614165, Verified ORF [yeastflysequest.fasta] Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia [Saccharomyces cerevisiae]gi\|2492817\|sp\|Q05998\|THI [nrdb_11152004_Chlamydomonas] THI7 SGDID:S000004227, Chr XII from 612369-614165, Verified ORF, "Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megalo [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Thi7p: thiamine transporter [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Thiamine transporter [nr-271106-contam.fasta] thiamin transport protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia; Thi7p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] THI7 SGDID:S000004227, Chr XII from 612369-614165, Verified ORF, "Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Thiamine transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THI7 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] THI7 SGDID:S000004227, Chr XII from 612367-614163, Genome Release 64-1-1, Verified ORF, "Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia" [yeast-030211-contam.fasta] THI7 SGDID:S000004227, Chr XII from 612367-614163, Genome Release 64-2-1, Verified ORF, "Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia" [20141208_orf_trans.fasta] YLR237W SGDID:S000004227, Chr XII from 612367-614163, Genome Release 64-1-1, Verified ORF, "Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	598 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IDA][IMP][ISS]
Biological Process:	thiamin transport [IMP][TAS]
Molecular Function:	thiamin transmembrane transporter activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFGSKVSRA LRFLEIPVKD RASVSFLKNP DLQPIKSANQ TWGFWSNFAY WGVMSFSVGT  60
   61 WMSASSALGV GLSYPETIGT FIVGDVLTII FTLANSCPGY DWKVGFTLAQ RFVFGIYGSA 120
  121 FGIIIRILMS IVNYGSNAWV GGLCINMILD SWSHHYLHLP NTLSSKVAMT TKELIGFIIF 180
  181 HVLTAFCYLM KPYHMNYILI WSCVATFFSM LGMVIYLAKQ AHGVGELFTS TKSTATGSTK 240
  241 AWAWVYMISY WFGSVSPGST NQSDYSRFGS SNWAIWAGTI CALLIPTTLI PVFGVIGAST 300
  301 CDKLYGEQYW MPMDIFNHWL TTNYSAGARA GAFFCGLSFV LSQMSYTISN CGFASGMDLA 360
  361 GLLPKYVDIK RGALFAACVS WACLPWNFYN SSSTFLTVMS SFGVVMTPII SVMICDNFLI 420
  421 RKRQYSITNA FILKGEYYFT KGVNWRAIVA WVCGMTPGLP GIAWEVNNDY FHNTGIVNFF 480
  481 YGDSFFSFLI SFFVYWGLCL LFPFKITVKH DDKDYYGAFT DEEARKKGMV PYSEISEEEI 540
  541 RAYTLGEGYT TGHEYRPEGS DDEIPELVKT SSENTNEFEI VHHKNNEKQS STASEKAA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		AGP2 BIO5 FEN2 MCH5 THI7 VHT1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SXM1	THI7	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	THI7	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..546]	Pfam	179.017729	Permease for cytosine/purines, uracil, thiamine, allantoin No confident structure predictions are available.
2	View Details	[547..598]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2