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Protein Overview: TFS1

General Information:
Name(s) found: TFS1 / YLR178C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 219 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    fungal-type vacuole membrane [IDALink to PubMed article]
    fungal-type vacuole lumen [IDALink to PubMed article]
    Biological Process: regulation of proteolysis [IDALink to PubMed article][IPILink to PubMed article]
    Molecular Function: peptidase inhibitor activity [IDALink to PubMed article]
    lipid binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQAIDFAQA SIDSYKKHGI LEDVIHDTSF QPSGILAVEY SSSAPVAMGN TLPTEKARSK  60
   61 PQFQFTFNKQ MQKSVPQANA YVPQDDDLFT LVMTDPDAPS KTDHKWSEFC HLVECDLKLL 120
  121 NEATHETSGA TEFFASEFNT KGSNTLIEYM GPAPPKGSGP HRYVFLLYKQ PKGVDSSKFS 180
  181 KIKDRPNWGY GTPATGVGKW AKENNLQLVA SNFFYAETK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) PET111 TFS1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TFS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] PSI-BLAST 146.69897 Phosphatidylethanolamine binding protein, PEBP


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle