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Protein Overview: PET309

General Information:
Name(s) found: PET309 / YLR067C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 965 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    integral to membrane [IDALink to PubMed article]
    mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: RNA metabolic process [IMPLink to PubMed article]
    aerobic respiration [IMPLink to PubMed article]
    translation [IMPLink to PubMed article]
    Molecular Function: translation regulator activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRCAPAVLR NYNYKKGIWS TGVPDHIRKL LRDKSTSPLC SQDERNLVSY FMARGSVPLK  60
   61 SVGSGLTKKA TTSITSNSAT TTFERQYLIK YLYRHQAYGN VIKIAQKFLY TTIGSQRLLK 120
  121 QDASLPELKK FLLSLLILQR GIQLDQAISD IIQRFLLTQK TMVIDLINSI FSRMVIMNMH 180
  181 EEAVYKWVKW MKLVNGHCEF TNYMENKIVL RNFLSFMRQS NVRPDYLSYL KAIQLTQGPA 240
  241 IASQFATTLL FLLTYIRKFS SAEAVWNYKC EHNLPIVSSD LTCILKTYCH MQKFNLVSST 300
  301 YWKYPDAQHD QNQFDYLLVA HSRLHNWDAL QQQFNALFGI GKLPSIQHYG ILMYTMARIG 360
  361 ELDSVNKLYT QLLRRGMIPT YAVLQSLLYA HYKVGDFAAC FSHFELFKKY DITPSTATHT 420
  421 IMLKVYRGLN DLDGAFRILK RLSEDPSVEI TEGHFALLIQ MCCKTTNHLI AQELFNLMTE 480
  481 HYNIQHTGKS ISALMDVYIE SNRPTEAIAL FEKHSKNLSW RDGLISVYNK AIKAYIGLRN 540
  541 ANKCEELFDK ITTSKLAVNS EFYKMMIKFL VTLNEDCETA LSIIDQLIKH SVIKVDATHF 600
  601 EIIMEAYDKE GYRDGIINLY KTMSQNKVPA NSKILYYILK AVAKKSLQNN EEIKETINMV 660
  661 EDIMENAANG TLDVTYNKLH PSVMAWPMRM IVKHDSPQRA LELYNRYNEL FFKKHDWISN 720
  721 NNKFVMMRSL LVLLAQIEQW KDFETLFAKY MDRIENIENL PSSTTPNIKL RSIFSGLFPY 780
  781 KVSQLIAMNK IDELPLLWKK LREKGFILDN ISWNSAVEAL FKDPRTLSYG MKIVDDTLIH 840
  841 GYNLIHKFRL LTKLSEDKTQ SSDKSWPTLK MKEKEPNKFQ PRLYLKSDTY NSIMRQLDTY 900
  901 LDGIDDLKTL EDQVRDFISN YKYFMKDYLL MPRSKINKWE QIEMRHLSYF KELRKSKRVL 960
  961 PVSKF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AEP1 AEP2 CBP6 CBS1 CBS2 MSS51 PET111 PET112 PET122 PET309 PET494 PET54 SUV3
    View Details Qiu et al. (2008) CBS1 CBS2 PET111 PET112 PET309 PET494 PET54

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PET309 Huh WK, et al. (2003)
    View Data PET309 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..692] MSA 32.646974 View MSA. No confident structure predictions are available.
    2 View Details [693..824] MSA 4.264997 View MSA. Confident ab initio structure predictions are available.
    3 View Details [825..965] MSA 1.081995 View MSA. No confident structure predictions are available.
    4 View Details [274..626] PSI-BLAST 9.154902 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
    5 View Details [627..807] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [808..965] MSA 3.293969 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein binding
    		•  2.67835748923436 bayes_pls_golite062009
  • binding
    		•  2.29041171814244 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.36301889945421 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.04482640570705 bayes_pls_golite062009
  • DNA binding
    		•  1.03582297487751 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.967526235944614 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.853542267130676 bayes_pls_golite062009
  • signal transducer activity
    		•  0.730941324269551 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.730941324269551 bayes_pls_golite062009
  • transcription activator activity
    		•  0.628603889499786 bayes_pls_golite062009
  • receptor activity
    		•  0.393899879588134 bayes_pls_golite062009
  • transcription factor activity
    		•  0.39224150319016 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle