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Protein Overview: MTD1

General Information:
Name(s) found: MTD1 / YKR080W [SGD]
Description(s) found:
Found 34 descriptions.
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  • NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 320 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: purine base biosynthetic process [IDALink to PubMed article][IMPLink to PubMed article]
    one-carbon metabolic process [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: methylenetetrahydrofolate dehydrogenase (NAD+) activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKPGRTILA SKVAETFNTE IINNVEEYKK THNGQGPLLV GFLANNDPAA KMYATWTQKT  60
   61 SESMGFRYDL RVIEDKDFLE EAIIQANGDD SVNGIMVYFP VFGNAQDQYL QQVVCKEKDV 120
  121 EGLNHVYYQN LYHNVRYLDK ENRLKSILPC TPLAIVKILE FLKIYNNLLP EGNRLYGKKC 180
  181 IVINRSEIVG RPLAALLAND GATVYSVDVN NIQKFTRGES LKLNKHHVED LGEYSEDLLK 240
  241 KCSLDSDVVI TGVPSENYKF PTEYIKEGAV CINFACTKNF SDDVKEKASL YVPMTGKVTI 300
  301 AMLLRNMLRL VRNVELSKEK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MTD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..17]
    [127..299]    		 PSI-BLAST 10091.522879 Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
    2 View Details [18..126]
    [300..320]    		 PSI-BLAST 10091.522879 Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.29686796649236 bayes_pls_golite062009
  • catalytic activity
    		•  2.0643953589843 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.95832530533882 bayes_pls_golite062009
  • malate dehydrogenase activity
    		•  1.78748747782382 bayes_pls_golite062009
  • DNA binding
    		•  1.70073234884672 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.47211855405194 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.43144163429682 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.39032308236663 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  1.2593557953787 bayes_pls_golite062009
  • transcription factor activity
    		•  0.9895904275677 bayes_pls_golite062009
  • malic enzyme activity
    		•  0.607811499947861 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.39426299750207 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  0.129148522173579 bayes_pls_golite062009
  • ligase activity
    		•  0.0191278372003161 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle