YRC Public Data Repository - Protein Structure Prediction

Protein:	MTD1
Organism:	Saccharomyces cerevisiae
Length:	320 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MTD1.

Description	E-value	Query Range	Subject Range
FOLD4_ARATH - Bifunctional protein FolD 4, chloroplastic OS=Arabidopsis thaliana GN=FOLD4 PE=1 SV=1	0.0	[5..314]	[69..356]
MTDC_MOUSE - Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Mus musculus G...	1.0E-99	[1..319]	[33..336]
gi\|9992889, gi\|4... - gi\|9992889\|gb\|AAG11417.1\|AF291429_1 C1-THFS protein [Yarrowia lipolytica], gi\|49649268\|emb\|CAG78978.... gi\|50551849, gi\|... - gi\|50551849\|ref\|XP_503399.1\| YALI0E01056p [Yarrowia lipolytica], gi\|49649268\|emb\|CAG78978.1\| YlC1-TH...	5.0E-99	[4..314]	[1..290]
gi\|25284865 - pir\|\|AE3573 methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) [imported] - Brucella melitensis (s... gi\|17988855, gi\|... - gi\|17988855\|ref\|NP_541488.1\| methylenetetrahydrofolate dehydrogenase / methenyltetrahydrofolate cycl... gi\|237787748, gi... - gi\|237816935\|ref\|ZP_04595927.1\| Methylenetetrahydrofolate dehydrogenase [Brucella abortus str. 2308 ... gi\|225615751, gi... - gi\|225629255\|ref\|ZP_03787288.1\| Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain...	9.0E-99	[4..313]	[21..310]
gi\|15458321, gi\|... - gi\|15902773\|ref\|NP_358323.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycloh... gi\|25284854 - pir\|\|A97963 methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) folD [imported] - Streptococcus pne...	2.0E-98	[2..315]	[20..303]
FOLD_BACSU - Bifunctional protein FolD OS=Bacillus subtilis (strain 168) GN=folD PE=3 SV=1 FOLD_BACSU - Bifunctional protein FolD OS=Bacillus subtilis GN=folD PE=3 SV=1 gi\|221323877 - gi\|221323877\|ref\|ZP_03605171.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su... gi\|221319601 - gi\|221319601\|ref\|ZP_03600895.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su... gi\|221314678 - gi\|221314678\|ref\|ZP_03596483.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su...	2.0E-98	[5..315]	[3..282]
MIS1 - Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation ... C1TM_YEAST - C-1-tetrahydrofolate synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...	3.0E-98	[7..320]	[37..329]
gi\|13699868, gi\|... - gi\|189065440\|dbj\|BAG35279.1\| unnamed protein product [Homo sapiens], gi\|14602585\|gb\|AAH09806.1\| Meth... gi\|168275806, gi... - gi\|168275806\|dbj\|BAG10623.1\| C-1-tetrahydrofolate synthase [synthetic construct], gi\|124000687\|gb\|AB...	7.0E-98	[4..313]	[3..293]

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Predicted Domain #1

Region A:
Residues: [1-17]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKPGRTILA SKVAETF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [127-299]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YYQNLYHNVR YLDKENRLKS ILPCTPLAIV KILEFLKIYN NLLPEGNRLY GKKCIVINRS  60
   61 EIVGRPLAAL LANDGATVYS VDVNNIQKFT RGESLKLNKH HVEDLGEYSE DLLKKCSLDS 120
  121 DVVITGVPSE NYKFPTEYIK EGAVCINFAC TKNFSDDVKE KASLYVPMTG KVT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10091.522879
Match:	1edzA_
Description:	Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.29686796649236	bayes_pls_golite062009
catalytic activity	2.0643953589843	bayes_pls_golite062009
transcription regulator activity	1.95832530533882	bayes_pls_golite062009
malate dehydrogenase activity	1.78748747782382	bayes_pls_golite062009
DNA binding	1.70073234884672	bayes_pls_golite062009
nucleic acid binding	1.47211855405194	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.43144163429682	bayes_pls_golite062009
oxidoreductase activity	1.39032308236663	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	1.2593557953787	bayes_pls_golite062009
transcription factor activity	0.9895904275677	bayes_pls_golite062009
malic enzyme activity	0.607811499947861	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.39426299750207	bayes_pls_golite062009
cyclohydrolase activity	0.129148522173579	bayes_pls_golite062009
ligase activity	0.0191278372003161	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [18-126]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTEIINNVEE YKKTHNGQGP LLVGFLANND PAAKMYATWT QKTSESMGFR YDLRVIEDKD  60
   61 FLEEAIIQAN GDDSVNGIMV YFPVFGNAQD QYLQQVVCKE KDVEGLNHV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [300-320]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IAMLLRNMLR LVRNVELSKE K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10091.522879
Match:	1edzA_
Description:	Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: