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Protein Overview: YKL171W

General Information:
Name(s) found: YKL171W [SGD]
Description(s) found:
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  • gi|6322677|ref|NP_012750.1| Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm; Ykl171wp [Saccharomyces cerevisiae] [NCBI NR]
  • gi|547785|sp|P36003.1|KKR1_YEAST RecName: Full=Probable serine/threonine-protein kinase YKL171W [NCBI NR]
  • pir||S38001 probable serine/threonine-specific protein kinase (EC 2.7.1.-) YKL171w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|486300|emb|CAA82013.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|407511|emb|CAA81516.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1582534|prf||2118403H ORF [NCBI NR]
  • Probable serine/threonine-protein kinase YKL171W OS=Saccharomyces cerevisiae GN=YKL171W PE=1 SV=1 [Swiss-Prot]
  • Weak similarity to ser/thr protein kinase [mips]
  • Putative protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm [SGD]
  • YKL171W, Chr XI from 127477-130263 [yeast_orfs2]
  • Chr XI from 127477-130263 [yeastorf3.fasta]
  • Chr XI from 127476-130262 [yeastorf4.fasta]
  • (P36003) Probable serine/threonine-protein kinase YKL171W (EC 2.7.1.-) [4932.FASTACCERV.txt]
  • YKL171W SGDID:S0001654, Chr XI from 127480-130266, Uncharacterized ORF [yeastflysequest.fasta]
  • Ykl171wp [Saccharomyces cerevisiae]gi|407511|emb|CAA81516.1| unknown [Saccharomyces cerevisiae]gi|486300|emb|CAA82013.1| unnamed protein product [Saccharomyces cerevisiae]gi|547785|sp|P36003|KKR1_YEAST Probable serine/threonine-protein kinase YKL171Wg [nrdb_11152004_Chlamydomonas]
  • (P36003) Probable serine/threonine-protein kinase YKL171W (EC 2.7.1.37) [cerv4932.FASTAC]
  • YKL171W SGDID:S000001654, Chr XI from 127480-130266, Uncharacterized ORF, "Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ORF [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm; Ykl171wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Probable serine/threonine-protein kinase YKL171W [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YKL171W SGDID:S000001654, Chr XI from 127480-130266, Uncharacterized ORF, "Putative protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • [chemostatdb.fasta]
  • NNK1 SGDID:S000001654, Chr XI from 127475-130261, Genome Release 64-1-1, Verified ORF, "Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm" [yeast-030211-contam.fasta]
  • NNK1 SGDID:S000001654, Chr XI from 127475-130261, Genome Release 64-2-1, Verified ORF, "Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm" [20141208_orf_trans.fasta]
  • YKL171W SGDID:S000001654, Chr XI from 127475-130261, Genome Release 64-1-1, Verified ORF, "Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 928 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: proteolysis [IPILink to PubMed article]
    Molecular Function: protein kinase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFTSQRQLRQ NGSPMSSSRS SQHSSGTASP ISDSPASNRS YGRDLRGLMG IDIPANEPAF  60
   61 NRANSSDTIY FRPKKIYKME HEHPSRSTLV QLQTRSQPDD VASSQVNPEG GTDDLELGDP 120
  121 CGNQSLYTIG AEYVPDLDFT KLVNEWQKST EDLYEFRSSA TPQVQIKDSG KGNYELWSSP 180
  181 DAILTQNKLR RDSFSQENSD SLSPEDSILS RNLHSKVKPI PLPRNSQQIF TPLSNLEAER 240
  241 RSSYTTSSNN NSITQNNKFS FAKLKYSLPT QSSAVPASFD SNASSLNFLP TTTLSTLSEL 300
  301 QISPNDMMDL IQKLPRNFLN LPYTQRKKVI IEHAPSHDYK AMMSLVKKFM LTSSRSNFSL 360
  361 AGFANNASVS QATANDDNIN SRNTPNNSND TYVNTRPLQR SRHGSIASQF LSSFSPSMTS 420
  421 IAKMNSNPLS GSAGGSARPD DKGMEILGHR LGKIIGFGAW GIIRECFDIE TGVGRVIKIV 480
  481 KFKGHQNIKK HVLREVAIWR TLKHNRILPL LDWKLDDNYA MYCLTERIND GTLYDLVISW 540
  541 DEFKRSKIPF AERCRLTIFL SLQLLSALKY MHSKTIVHGD IKLENCLLQK EGKKSDWKVF 600
  601 LCDFGMSCHF DEKHVYRNDT FDENLSSGNS HRKRKSIEQT NLIKYPTTNF LPDDRTNDFD 660
  661 ASENLKYQFE NRKHQPFTPK GMVSSSSHSL KHLNQPSSSS SSNLFHKPAS QPQPQHRSPF 720
  721 HGRHKTTDFS NLEPEPSKYI GSLPYASPEL LRYSDARRSK SVEMHIYDSP DSSQSEISAA 780
  781 SSSSSNLSSL SSSTKASAVT NSGVTTSSPS GSSTDFPCIV SPLGPASDIW ALGVMLYTML 840
  841 VGKLPFNHEF EPRLRSLIKV GEFDRFSLAQ VCKFDRKKNE GTIGQGLYDT VIGCLTIDLD 900
  901 KRWKLKRIEE VLQNEMNLSE AIHDNNGS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RPN1 YKL171W 2 Unpublished Fields Lab Data
    View Screen YPT31 YKL171W 1 Unpublished Fields Lab Data
    View Screen CDC4 YKL171W 1 Unpublished Fields Lab Data
    View Screen YKL171W REV7 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..401] deduced N/A No confident structure predictions are available.
    2 View Details [402..530]
    [739..781]    		 PSI-BLAST 167.54902 Calmodulin-dependent protein kinase
    3 View Details [531..738] PSI-BLAST 167.54902 Calmodulin-dependent protein kinase
    4 View Details [782..928] MSA 1.326968 View MSA. No confident structure predictions are available.
    5 View Details [780..928] FFAS03 7.41 Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • protein kinase activity
    		•  2.5838644943424 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.45273401254881 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  2.32609718275273 bayes_pls_golite062009
  • kinase activity
    		•  2.25271639892273 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.87817787385115 bayes_pls_golite062009
  • binding
    		•  1.41489581155645 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • transferase activity
    		•  1.02325581375333 bayes_pls_golite062009
  • protein binding
    		•  0.481719236497011 bayes_pls_golite062009
  • ATP binding
    		•  0.43842367748426 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.395712570017132 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.381353295672519 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.222536651626411 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.222477512452933 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.213888799799513 bayes_pls_golite062009
  • nucleotide binding
    		•  0.208281379222054 bayes_pls_golite062009
  • peptidase activity
    		•  0.00308643640382985 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle