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Protein Overview: JHD2

General Information:
Name(s) found: JHD2 / YJR119C [SGD]
Description(s) found:
Found 31 descriptions.
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  • JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 728 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: histone demethylation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: histone demethylase activity (H3-K4 specific) [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEIPALYPT EQEFKNPIDY LSNPHIKRLG VRYGMVKVVP PNGFCPPLSI DMENFTFQPR  60
   61 IQNLENLDLK NRCRLFFMKQ LNNFKRSVKD PSKLILREPY TIVEYSDSTH ASEILKKKVY 120
  121 FYDVFSELIK DNRTLTDTTQ SFRRKLKFRD ISQLRGDISL WRTISKKFNV PIGLLKEIFE 180
  181 KYIASYYIFL HSLNENVHTA LHADQYPKSL LSDDEDDFDL GPDSNSGSDF EEDDDDACIV 240
  241 CRKTNDPKRT ILCDSCDKPF HIYCLSPPLE RVPSGDWICN TCIVGNGYYG FTQDTHDYSL 300
  301 PEFQEYCKRQ NSRLLPARKL SIDELEEMFW SLVTKNRRSS LTTVKYGADI HNELPGQITG 360
  361 FPTREFIPKN INGDELIDYL KYCDHPMNLT NLPMAHNSLL PLFKRNISGM TIPWIYIGSL 420
  421 FSTFCWHMED QYTLSANYQH EGDPKVWYSI PESGCTKFND LLNDMSPDLF IKQPDLLHQL 480
  481 VTLISPYDPN FKKSGIPVYK AVQKPNEYII TFPKCYHAGF NTGYNFNEAV NFTIDFWLPY 540
  541 GFGAITDYKL TQKACVFDMF DLMINVLDKY NKDTLLFNDA FVRQCYSSLI VFYNTELKRI 600
  601 RKIQAIVPRT TLLEVHTDPN DEDEEYDIFC SQCKTICSIA FVLRKNNYDS IRTYKRHKKN 660
  661 HLSIRQWNEL STTDSKVSIL CTQDYLKSIQ NLNNSDGEEP YIDDELYFTK SLKDIDSLIK 720
  721 QVGVKLDR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) JHD2 MPP10 SAS10 UGP1 UTP25

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data JHD2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..70] Pfam 25.69897 jmjN domain No confident structure predictions are available.
    2 View Details [71..231] deduced N/A No confident structure predictions are available.
    3 View Details [232..318] PSI-BLAST 98.980454 Williams-Beuren syndrome transcription factor, WSTF
    4 View Details [319..377] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [378..554] ORFEUS 8.33 Hypoxia-inducible factor HIF ihhibitor (FIH1)
    6 View Details [555..728] MSA 2.054989 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle