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View Structure Prediction Details

Protein: JHD2
Organism: Saccharomyces cerevisiae
Length: 728 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for JHD2.

Description E-value Query
Range
Subject
Range
JHD2_YEAST - Histone demethylase JHD2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=JHD2 PE=1 SV=1
JHD2 - JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups s...
0.0 [1..728] [1..728]
gi|19923370, gi|... - gi|6572291|emb|CAB63108.1| RB-binding protein [Homo sapiens], ref|NP_006609.2| Jumonji, AT rich inte...
0.0 [2..687] [167..886]
gi|25404909, gi|... - gi|6633837|gb|AAF19696.1|AC008047_3 F2K11.14 [Arabidopsis thaliana], pir||D96660 protein F2K11.14 [i...
0.0 [5..674] [32..664]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [130..687] [1..555]
gi|83029787, gi|... - gi|83029787|ref|XP_906119.1| PREDICTED: jumonji, AT rich interactive domain 1A (Rbp2 like) isoform 5...
0.0 [2..547] [17..602]
jmj2 - histone demethylase Jmj2
JMJ2_SCHPO - Jumonji/ARID domain-containing protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=j...
0.0 [1..671] [57..696]
gi|16944479, gi|... - gi|32412502|ref|XP_326731.1| hypothetical protein [Neurospora crassa], gi|28923151|gb|EAA32368.1| hy...
gi|85103796 - gi|85103796|ref|XP_961604.1| hypothetical protein NCU01238 [Neurospora crassa OR74A]
0.0 [34..677] [272..903]

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Predicted Domain #1
Region A:
Residues: [1-70]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEIPALYPT EQEFKNPIDY LSNPHIKRLG VRYGMVKVVP PNGFCPPLSI DMENFTFQPR  60
   61 IQNLENLDLK 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 25.69897
Match: PF02375
Description: jmjN domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [71-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRCRLFFMKQ LNNFKRSVKD PSKLILREPY TIVEYSDSTH ASEILKKKVY FYDVFSELIK  60
   61 DNRTLTDTTQ SFRRKLKFRD ISQLRGDISL WRTISKKFNV PIGLLKEIFE KYIASYYIFL 120
  121 HSLNENVHTA LHADQYPKSL LSDDEDDFDL GPDSNSGSDF E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [232-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDDDDACIVC RKTNDPKRTI LCDSCDKPFH IYCLSPPLER VPSGDWICNT CIVGNGYYGF  60
   61 TQDTHDYSLP EFQEYCKRQN SRLLPAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.980454
Match: 1f62A_
Description: Williams-Beuren syndrome transcription factor, WSTF
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [319-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLSIDELEEM FWSLVTKNRR SSLTTVKYGA DIHNELPGQI TGFPTREFIP KNINGDELI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.646 0.932 nucleus a.4.1 Homeodomain-like

Predicted Domain #5
Region A:
Residues: [378-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYLKYCDHPM NLTNLPMAHN SLLPLFKRNI SGMTIPWIYI GSLFSTFCWH MEDQYTLSAN  60
   61 YQHEGDPKVW YSIPESGCTK FNDLLNDMSP DLFIKQPDLL HQLVTLISPY DPNFKKSGIP 120
  121 VYKAVQKPNE YIITFPKCYH AGFNTGYNFN EAVNFTIDFW LPYGFGAITD YKLTQKA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.33
Match: 1mzeA
Description: Hypoxia-inducible factor HIF ihhibitor (FIH1)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [555-728]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CVFDMFDLMI NVLDKYNKDT LLFNDAFVRQ CYSSLIVFYN TELKRIRKIQ AIVPRTTLLE  60
   61 VHTDPNDEDE EYDIFCSQCK TICSIAFVLR KNNYDSIRTY KRHKKNHLSI RQWNELSTTD 120
  121 SKVSILCTQD YLKSIQNLNN SDGEEPYIDD ELYFTKSLKD IDSLIKQVGV KLDR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle