YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: JHD2
Organism: Saccharomyces cerevisiae
Length: 728 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for JHD2.

Description E-value Query
Range
Subject
Range
JHD2_YEAST - Histone demethylase JHD2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=JHD2 PE=1 SV=1
JHD2 - JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups s...
0.0 [1..728] [1..728]
gi|19923370, gi|... - gi|6572291|emb|CAB63108.1| RB-binding protein [Homo sapiens], ref|NP_006609.2| Jumonji, AT rich inte...
0.0 [2..687] [167..886]
gi|25404909, gi|... - gi|6633837|gb|AAF19696.1|AC008047_3 F2K11.14 [Arabidopsis thaliana], pir||D96660 protein F2K11.14 [i...
0.0 [5..674] [32..664]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [130..687] [1..555]
gi|83029787, gi|... - gi|83029787|ref|XP_906119.1| PREDICTED: jumonji, AT rich interactive domain 1A (Rbp2 like) isoform 5...
0.0 [2..547] [17..602]
jmj2 - histone demethylase Jmj2
JMJ2_SCHPO - Jumonji/ARID domain-containing protein 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=j...
0.0 [1..671] [57..696]
gi|16944479, gi|... - gi|32412502|ref|XP_326731.1| hypothetical protein [Neurospora crassa], gi|28923151|gb|EAA32368.1| hy...
gi|85103796 - gi|85103796|ref|XP_961604.1| hypothetical protein NCU01238 [Neurospora crassa OR74A]
0.0 [34..677] [272..903]

Back

Predicted Domain #1
Region A:
Residues: [1-70]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEIPALYPT EQEFKNPIDY LSNPHIKRLG VRYGMVKVVP PNGFCPPLSI DMENFTFQPR  60
   61 IQNLENLDLK 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 25.69897
Match: PF02375
Description: jmjN domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [71-231]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRCRLFFMKQ LNNFKRSVKD PSKLILREPY TIVEYSDSTH ASEILKKKVY FYDVFSELIK  60
   61 DNRTLTDTTQ SFRRKLKFRD ISQLRGDISL WRTISKKFNV PIGLLKEIFE KYIASYYIFL 120
  121 HSLNENVHTA LHADQYPKSL LSDDEDDFDL GPDSNSGSDF E

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.343 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.303 a.1.1 Globin-like
View Download 0.246 f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.263 a.133.1 Phospholipase A2, PLA2
View Download 0.327 a.131.1 Peridinin-chlorophyll protein
View Download 0.235 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.230 a.118.1 ARM repeat
View Download 0.216 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.215 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain

Predicted Domain #3
Region A:
Residues: [232-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDDDDACIVC RKTNDPKRTI LCDSCDKPFH IYCLSPPLER VPSGDWICNT CIVGNGYYGF  60
   61 TQDTHDYSLP EFQEYCKRQN SRLLPAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 98.980454
Match: 1f62A_
Description: Williams-Beuren syndrome transcription factor, WSTF
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [319-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KLSIDELEEM FWSLVTKNRR SSLTTVKYGA DIHNELPGQI TGFPTREFIP KNINGDELI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.646 0.932 nucleus a.4.1 Homeodomain-like
View Download 0.611 0.932 nucleus a.64.1 Saposin
View Download 0.460 0.932 nucleus d.186.1 Head-to-tail joining protein W, gpW
View Download 0.543 0.932 nucleus g.63.1 Mollusk pheromone
View Download 0.542 0.932 nucleus a.4.1 Homeodomain-like
View Download 0.485 0.932 nucleus a.1.1 Globin-like
View Download 0.450 0.932 nucleus a.64.2 Bacteriocin AS-48
View Download 0.443 0.932 nucleus a.20.1 PGBD-like
View Download 0.414 0.932 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.387 0.932 nucleus a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.373 0.932 nucleus a.178.1 Soluble domain of poliovirus core protein 3a
View Download 0.370 0.932 nucleus c.32.1 Tubulin/Dihydroxyacetone kinase nucleotide-binding domain
View Download 0.339 0.932 nucleus a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.339 0.932 nucleus a.1.1 Globin-like
View Download 0.330 0.932 nucleus a.1.1 Globin-like
View Download 0.313 0.932 nucleus a.163.1 Crustacean CHH/MIH/GIH neurohormone
View Download 0.311 0.932 nucleus a.58.1 Chemotaxis receptor methyltransferase CheR, N-terminal domain
View Download 0.298 0.932 nucleus d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.297 0.932 nucleus d.8.1 Urease, gamma-subunit
View Download 0.295 0.932 nucleus d.64.1 eIF1-like
View Download 0.288 0.932 nucleus a.4.8 Ribosomal protein S18
View Download 0.288 0.932 nucleus d.39.1 Dynein light chain 8 (DLC8)
View Download 0.271 0.932 nucleus a.4.1 Homeodomain-like
View Download 0.267 0.932 nucleus d.58.3 Protease propeptides/inhibitors
View Download 0.266 0.932 nucleus a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.265 0.932 nucleus d.58.8 Viral DNA-binding domain
View Download 0.262 0.932 nucleus a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.255 0.932 nucleus a.39.1 EF-hand
View Download 0.255 0.932 nucleus a.4.1 Homeodomain-like
View Download 0.254 0.932 nucleus d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.247 0.932 nucleus a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.246 0.932 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.244 0.932 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.240 0.932 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.240 0.932 nucleus a.64.1 Saposin
View Download 0.231 0.932 nucleus a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.218 0.932 nucleus a.4.1 Homeodomain-like
View Download 0.214 0.932 nucleus a.22.1 Histone-fold
View Download 0.212 0.932 nucleus a.4.1 Homeodomain-like
View Download 0.209 0.932 nucleus a.4.5 "Winged helix" DNA-binding domain
View Download 0.208 0.932 nucleus a.3.1 Cytochrome c
View Download 0.201 0.932 nucleus a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #5
Region A:
Residues: [378-554]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYLKYCDHPM NLTNLPMAHN SLLPLFKRNI SGMTIPWIYI GSLFSTFCWH MEDQYTLSAN  60
   61 YQHEGDPKVW YSIPESGCTK FNDLLNDMSP DLFIKQPDLL HQLVTLISPY DPNFKKSGIP 120
  121 VYKAVQKPNE YIITFPKCYH AGFNTGYNFN EAVNFTIDFW LPYGFGAITD YKLTQKA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.33
Match: 1mzeA
Description: Hypoxia-inducible factor HIF ihhibitor (FIH1)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [555-728]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CVFDMFDLMI NVLDKYNKDT LLFNDAFVRQ CYSSLIVFYN TELKRIRKIQ AIVPRTTLLE  60
   61 VHTDPNDEDE EYDIFCSQCK TICSIAFVLR KNNYDSIRTY KRHKKNHLSI RQWNELSTTD 120
  121 SKVSILCTQD YLKSIQNLNN SDGEEPYIDD ELYFTKSLKD IDSLIKQVGV KLDR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.485 0.726 cytoplasm a.1.1 Globin-like
View Download 0.370 0.069 cytoplasm c.32.1 Tubulin/Dihydroxyacetone kinase nucleotide-binding domain
View Download 0.266 0.025 cytoplasm a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.246 N/A N/A d.127.1 Creatinase/aminopeptidase
View Download 0.228 N/A N/A a.1.1 Globin-like
View Download 0.205 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.202 N/A N/A a.22.1 Histone-fold


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle