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Protein Overview: ILV3

General Information:
Name(s) found: ILV3 / YJR016C [SGD]
Description(s) found:
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  • gi|854590|emb|CAA60939.1| dihydroxyacid dehydratase [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6322476|ref|NP_012550.1| Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids; Ilv3p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1170543|sp|P39522.2|ILV3_YEAST RecName: Full=Dihydroxy-acid dehydratase, mitochondrial; Short=DAD; AltName: Full=2,3-dihydroxy acid hydrolyase; Flags: Precursor [NCBI NR]
  • pir||S55205 dihydroxy-acid dehydratase (EC 4.2.1.9) - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1015650|emb|CAA89540.1| ILV3 [Saccharomyces cerevisiae] [NCBI NR]
  • Dihydroxy-acid dehydratase, mitochondrial OS=Saccharomyces cerevisiae GN=ILV3 PE=1 SV=2 [Swiss-Prot]
  • ILV3 Dihydroxy-acid dehydratase [mips]
  • Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids [SGD]
  • ILV3, Chr X from 464143-465900, reverse complement [yeast_orfs2]
  • Chr X from 464143-465900, reverse complement [yeastorf3.fasta]
  • Chr X from 464144-465901, reverse complement [yeastorf4.fasta]
  • Chr X from 465902-464145, reverse complement [yeastorf5.fasta]
  • (P39522) Dihydroxy-acid dehydratase, mitochondrial precursor (EC 4.2.1.9) (DAD) (2,3-dihydroxy acid hydrolyase) [4932.FASTACCERV.txt]
  • ILV3 SGDID:S0003777, Chr X from 466122-464365, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids [Saccharomyces cerevisiae]gi|1015650|emb|CAA89540.1| ILV3 [Saccharomyces cerevisiae]gi|854590|emb|CAA60939.1| dihydroxyacid dehyd [nrdb_11152004_Chlamydomonas]
  • ILV3 SGDID:S000003777, Chr X from 466122-464365, reverse complement, Verified ORF, "Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ILV3 SGDID:S000003777, Chr X from 466201-464444, reverse complement, Verified ORF, "Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" [yeast-contam.fasta]
  • ILV3 SGDID:S000003777, Chr X from 466200-464443, reverse complement, Verified ORF, "Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" [yeast-200209-contam.fasta]
  • dihydroxyacid dehydratase [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids; Ilv3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ILV3 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Dihydroxy-acid dehydratase, mitochondrial precursor (DAD) (2,3-dihydroxy acid hydrolyase) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Dihydroxy-acid dehydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ILV3 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ILV3 SGDID:S000003777, Chr X from 466208-464451, Genome Release 64-1-1, reverse complement, Verified ORF, "Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" [yeast-030211-contam.fasta]
  • ILV3 SGDID:S000003777, Chr X from 466208-464451, Genome Release 64-2-1, reverse complement, Verified ORF, "Dihydroxyacid dehydratase; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" [20141208_orf_trans.fasta]
  • YJR016C SGDID:S000003777, Chr X from 466208-464451, Genome Release 64-1-1, reverse complement, Verified ORF, "Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 585 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    Biological Process: branched chain family amino acid biosynthetic process [TASLink to PubMed article]
    Molecular Function: dihydroxy-acid dehydratase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLLTKVATS RQFSTTRCVA KKLNKYSYII TEPKGQGASQ AMLYATGFKK EDFKKPQVGV  60
   61 GSCWWSGNPC NMHLLDLNNR CSQSIEKAGL KAMQFNTIGV SDGISMGTKG MRYSLQSREI 120
  121 IADSFETIMM AQHYDANIAI PSCDKNMPGV MMAMGRHNRP SIMVYGGTIL PGHPTCGSSK 180
  181 ISKNIDIVSA FQSYGEYISK QFTEEEREDV VEHACPGPGS CGGMYTANTM ASAAEVLGLT 240
  241 IPNSSSFPAV SKEKLAECDN IGEYIKKTME LGILPRDILT KEAFENAITY VVATGGSTNA 300
  301 VLHLVAVAHS AGVKLSPDDF QRISDTTPLI GDFKPSGKYV MADLINVGGT QSVIKYLYEN 360
  361 NMLHGNTMTV TGDTLAERAK KAPSLPEGQE IIKPLSHPIK ANGHLQILYG SLAPGGAVGK 420
  421 ITGKEGTYFK GRARVFEEEG AFIEALERGE IKKGEKTVVV IRYEGPRGAP GMPEMLKPSS 480
  481 ALMGYGLGKD VALLTDGRFS GGSHGFLIGH IVPEAAEGGP IGLVRDGDEI IIDADNNKID 540
  541 LLVSDKEMAQ RKQSWVAPPP RYTRGTLSKY AKLVSNASNG CVLDA

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) ACS2 CAR2 DLD3 DUG1 ERG10 FUM1 ILV3 RHO1 WTM1
    View Details Qiu et al. (2008) ILV1 ILV3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ILV3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] ORFEUS 9.48 Histidine ammonia-lyase (HAL)
    2 View Details [101..130]
    [396..585]    		 ORFEUS 8.9 Putative glycerate kinase (hypothetical protein TM1585)
    3 View Details [131..395] ORFEUS 8.9 Putative glycerate kinase (hypothetical protein TM1585)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3-isopropylmalate dehydratase activity
    		•  5.35660492472618 bayes_pls_golite062009
  • catalytic activity
    		•  1.61959327305722 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  1.16841092671386 bayes_pls_golite062009
  • hydro-lyase activity
    		•  1.13002130445077 bayes_pls_golite062009
  • lyase activity
    		•  1.11228159918123 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle