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Protein Overview: SET2

General Information:
Name(s) found: SET2 / YJL168C [SGD]
Description(s) found:
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  • gi|6322293|ref|NP_012367.1| Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation statu [NCBI NR]
  • gi|1353031|sp|P46995.1|SET2_YEAST RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 specific; AltName: Full=SET domain-containing protein 2; AltName: Full=Lysine N-methyltransferase 3 [NCBI NR]
  • pir||S56951 hypothetical protein YJL168c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1008361|emb|CAA89464.1| EZL1 [Saccharomyces cerevisiae] [NCBI NR]
  • Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Saccharomyces cerevisiae GN=SET2 PE=1 SV=1 [Swiss-Prot]
  • SET2 Enhancer of zeste-like [mips]
  • Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p [SGD]
  • SET2, Chr X from 102219-104420, reverse complement [yeast_orfs2]
  • Chr X from 102219-104420, reverse complement [yeastorf3.fasta]
  • Chr X from 104420-102219, reverse complement [yeastorf5.fasta]
  • (P46995) SET domain protein 2 [4932.FASTACCERV.txt]
  • SET2 SGDID:S0003704, Chr X from 104421-102220, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p [Saccharomyces c [nrdb_11152004_Chlamydomonas]
  • SET2 SGDID:S000003704, Chr X from 104421-102220, reverse complement, Verified ORF, "Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone me [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • SET2 SGDID:S000003704, Chr X from 104422-102221, reverse complement, Verified ORF, "Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone me [yeast-contam.fasta]
  • SET domain-containing protein 2 [nr-271106-contam.fasta]
  • Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p; Set2p [Saccharo [nr-271106-contam.fasta]
  • EZL1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • SET2 SGDID:S000003704, Chr X from 104422-102221, reverse complement, Verified ORF, "Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 733 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: ascospore formation [IMPLink to PubMed article]
    RNA elongation [IDALink to PubMed article][IPILink to PubMed article]
    histone methylation [IDALink to PubMed article][IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: histone methyltransferase activity [ISSLink to PubMed articleLink to PubMed article]
    histone methyltransferase activity (H3-K36 specific) [IDALink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNQSVSAS EDEKEILNNN AEGHKPQRLF DQEPDLTEEA LTKFENLDDC IYANKRIGTF  60
   61 KNNDFMECDC YEEFSDGVNH ACDEDSDCIN RLTLIECVND LCSSCGNDCQ NQRFQKKQYA 120
  121 PIAIFKTKHK GYGVRAEQDI EANQFIYEYK GEVIEEMEFR DRLIDYDQRH FKHFYFMMLQ 180
  181 NGEFIDATIK GSLARFCNHS CSPNAYVNKW VVKDKLRMGI FAQRKILKGE EITFDYNVDR 240
  241 YGAQAQKCYC EEPNCIGFLG GKTQTDAASL LPQNIADALG VTVSMEKKWL KLKKLSGEPI 300
  301 IKNENENINI EFLQSLEVQP IDSPVDVTKI MSVLLQQDNK IIASKLLKRL FTIDDDSLRH 360
  361 QAIKLHGYTC FSKMLKLFIT EQPQVDGKGN ETEEDDIKFI KGILDFLLEL PKTTRNGIES 420
  421 SQIDNVVKTL PAKFPFLKPN CDELLEKWSK FETYKRITKK DINVAASKMI DLRRVRLPPG 480
  481 WEIIHENGRP LYYNAEQKTK LHYPPSGSSK VFSSRSNTQV NSPSSSGIPK TPGALDSKKH 540
  541 KLSDEEYERK KQKRLEYERI ALERAKQEEL ESLKQKLKLE NERKSVLEDI IAEFNKQKEL 600
  601 QKEESKKLVE AKEAKRLKRK TVSQSQRLEH NWNKFFASFV PNLIKKNPQS KQFDHENIKQ 660
  661 CAKDIVKILT TKELKKDSSR APPDDLTKGK RHKVKEFINS YMDKIILKKK QKKALGLSSA 720
  721 STRMSSPPPS TSS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ICL1 SET2 TRP4
    View Details Gavin AC, et al. (2002) SET2 UTP22

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample zds1 from august 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CTF13 SET2 1 Unpublished Fields Lab Data
    View Screen SWI5 SET2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SET2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] deduced N/A No confident structure predictions are available.
    2 View Details [90..279] Pfam 64.031517 SET domain No confident structure predictions are available.
    3 View Details [280..733] deduced N/A No confident structure predictions are available.
    4 View Details [608..733] PSI-BLAST 36.30103 Structure and CTD binding of the Set2 SRI domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle