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Protein Overview: TRP4

General Information:
Name(s) found: TRP4 / YDR354W [SGD]
Description(s) found:
Found 35 descriptions.
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  • Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 380 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: tryptophan biosynthetic process [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: anthranilate phosphoribosyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEATLLSYT KKLLASPPQL SSTDLHDALL VILSLLQKCD TNSDESLSIY TKVSSFLTAL  60
   61 RVTKLDHKAE YIAEAAKAVL RHSDLVDLPL PKKDELHPED GPVILDIVGT GGDGQNTFNV 120
  121 STSAAIVASG IQGLKICKHG GKASTSNSGA GDLIGTLGCD MFKVNSSTVP KLWPDNTFMF 180
  181 LLAPFFHHGM GHVSKIRKFL GIPTVFNVLG PLLHPVSHVN KRILGVYSKE LAPEYAKAAA 240
  241 LVYPGSETFI VWGHVGLDEV SPIGKTTVWH IDPTSSELKL KTFQLEPSMF GLEEHELSKC 300
  301 ASYGPKENAR ILKEEVLSGK YHLGDNNPIY DYILMNTAVL YCLSQGHQNW KEGIIKAEES 360
  361 IHSGNALRSL EHFIDSVSSL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ICL1 SET2 TRP4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data TRP4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..82]
    [187..221]    		 PSI-BLAST 63.69897 Pyrimidine nucleoside phosphorylase
    2 View Details [83..186]
    [222..380]    		 PSI-BLAST 63.69897 Pyrimidine nucleoside phosphorylase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • anthranilate phosphoribosyltransferase activity
    		•  4.81240054558791 bayes_pls_golite062009
  • transferase activity, transferring pentosyl groups
    		•  2.10935430322097 bayes_pls_golite062009
  • catalytic activity
    		•  1.99182579317454 bayes_pls_golite062009
  • transferase activity
    		•  1.94624792134779 bayes_pls_golite062009
  • binding
    		•  1.79881039015627 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  1.10712828233974 bayes_pls_golite062009
  • protein binding
    		•  0.332591807861153 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle