YRC Public Data Repository - Protein Structure Prediction

Protein:	TRP4
Organism:	Saccharomyces cerevisiae
Length:	380 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRP4.

Description	E-value	Query Range	Subject Range
gi\|207346402 - gi\|207346402\|gb\|EDZ72909.1\| YDR354Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190404709 - gi\|190404709\|gb\|EDV07976.1\| anthranilate phosphoribosyltransferase [Saccharomyces cerevisiae RM11-1a... TRPD_YEAST - Anthranilate phosphoribosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=T... TRP4 - Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosph... gi\|151942328 - gi\|151942328\|gb\|EDN60684.1\| anthranilate phosphoribosyl transferase [Saccharomyces cerevisiae YJM789...	5.0E-98	[1..380]	[1..380]
TRPD_METJA - Anthranilate phosphoribosyltransferase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 266... TRPD_METJA - Anthranilate phosphoribosyltransferase OS=Methanocaldococcus jannaschii GN=trpD PE=3 SV=1	2.0E-92	[30..376]	[4..332]
TRPD_PSEPU - Anthranilate phosphoribosyltransferase OS=Pseudomonas putida GN=trpD PE=3 SV=1	8.0E-89	[27..377]	[2..340]
TRPD_BRADU - Anthranilate phosphoribosyltransferase OS=Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 1362... TRPD_BRAJA - Anthranilate phosphoribosyltransferase OS=Bradyrhizobium japonicum GN=trpD PE=3 SV=1	1.0E-88	[25..379]	[1..337]
TRPD_AZOBR - Anthranilate phosphoribosyltransferase OS=Azospirillum brasilense GN=trpD PE=3 SV=1	7.0E-87	[16..379]	[2..345]
gi\|47097467, gi\|... - gi\|47097467\|ref\|ZP_00235011.1\| anthranilate phosphoribosyltransferase [Listeria monocytogenes str. 1... TRPD_LISMO - Anthranilate phosphoribosyltransferase OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 /... gi\|224501426 - gi\|224501426\|ref\|ZP_03669733.1\| anthranilate phosphoribosyltransferase [Listeria monocytogenes FSL R... TRPD_LISMO - Anthranilate phosphoribosyltransferase OS=Listeria monocytogenes GN=trpD PE=3 SV=1 gi\|254898201, gi... - gi\|254898201\|ref\|ZP_05258125.1\| anthranilate phosphoribosyltransferase [Listeria monocytogenes J0161... gi\|127633616, gi... - gi\|254832033\|ref\|ZP_05236688.1\| anthranilate phosphoribosyltransferase [Listeria monocytogenes 10403... gi\|254912306, gi... - gi\|254912306\|ref\|ZP_05262318.1\| anthranilate phosphoribosyltransferase [Listeria monocytogenes J2818... gi\|133733141, gi... - gi\|254936633\|ref\|ZP_05268330.1\| anthranilate phosphoribosyltransferase [Listeria monocytogenes F6900...	3.0E-86	[31..378]	[4..334]
TRPD_RHILO - Anthranilate phosphoribosyltransferase OS=Rhizobium loti GN=trpD PE=3 SV=1 TRPD_RHILO - Anthranilate phosphoribosyltransferase OS=Rhizobium loti (strain MAFF303099) GN=trpD PE=3 SV=1	2.0E-85	[25..379]	[1..336]
TRPD_LISIN - Anthranilate phosphoribosyltransferase OS=Listeria innocua GN=trpD PE=3 SV=1 TRPD_LISIN - Anthranilate phosphoribosyltransferase OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=trpD PE...	3.0E-85	[31..378]	[4..334]
gi\|25286973 - gi\|25286973\|pir\|\|F84962 anthranilate phosphoribosyltransferase (EC 2.4.2.18) [imported] - Buchnera s... TRPD_BUCAI - Anthranilate phosphoribosyltransferase OS=Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS... TRPD_BUCAI - Anthranilate phosphoribosyltransferase OS=Buchnera aphidicola subsp. Acyrthosiphon pisum GN=trpD PE=... TRPD_BUCA5 - Anthranilate phosphoribosyltransferase OS=Buchnera aphidicola subsp. Acyrthosiphon pisum (strain 5A)... gi\|257471334\|ref... - anthranilate phosphoribosyltransferase [Buchnera aphidicola str. LSR1 (Acyrthosiphon pisum)]	5.0E-85	[28..374]	[1..329]
gi\|6492281 - gi\|6492281\|gb\|AAF14252.1\|AF132318_2 phosphoribosyl anthranilate transferase [Buchnera aphidicola] TRPD_BUCMH - Anthranilate phosphoribosyltransferase OS=Buchnera aphidicola subsp. Melaphis rhois GN=trpD PE=3 SV=...	9.0E-85	[31..376]	[4..331]

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Predicted Domain #1

Region A:
Residues: [1-82]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEATLLSYT KKLLASPPQL SSTDLHDALL VILSLLQKCD TNSDESLSIY TKVSSFLTAL  60
   61 RVTKLDHKAE YIAEAAKAVL RH

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [187-221]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HHGMGHVSKI RKFLGIPTVF NVLGPLLHPV SHVNK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.69897
Match:	1brwA_
Description:	Pyrimidine nucleoside phosphorylase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
anthranilate phosphoribosyltransferase activity	4.81240054558791	bayes_pls_golite062009
transferase activity, transferring pentosyl groups	2.10935430322097	bayes_pls_golite062009
catalytic activity	1.99182579317454	bayes_pls_golite062009
transferase activity	1.94624792134779	bayes_pls_golite062009
binding	1.79881039015627	bayes_pls_golite062009
transferase activity, transferring glycosyl groups	1.10712828233974	bayes_pls_golite062009
protein binding	0.332591807861153	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [83-186]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDLVDLPLPK KDELHPEDGP VILDIVGTGG DGQNTFNVST SAAIVASGIQ GLKICKHGGK  60
   61 ASTSNSGAGD LIGTLGCDMF KVNSSTVPKL WPDNTFMFLL APFF

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [222-380]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RILGVYSKEL APEYAKAAAL VYPGSETFIV WGHVGLDEVS PIGKTTVWHI DPTSSELKLK  60
   61 TFQLEPSMFG LEEHELSKCA SYGPKENARI LKEEVLSGKY HLGDNNPIYD YILMNTAVLY 120
  121 CLSQGHQNWK EGIIKAEESI HSGNALRSLE HFIDSVSSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.69897
Match:	1brwA_
Description:	Pyrimidine nucleoside phosphorylase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: