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Protein Overview: JEM1

General Information:
Name(s) found: JEM1 / YJL073W [SGD]
Description(s) found:
Found 19 descriptions.
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  • DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 645 amino acids

    Gene Ontology:
    Cellular Component: nuclear membrane-endoplasmic reticulum network [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    peripheral to membrane of membrane fraction [IDALink to PubMed article]
    Biological Process: karyogamy involved in conjugation with cellular fusion [IGILink to PubMed article][IMPLink to PubMed article]
    protein folding [IGILink to PubMed article]
    ER-associated protein catabolic process [IMPLink to PubMed article]
    Molecular Function: chaperone binding [ISSLink to PubMed article]
    unfolded protein binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILISGYCLL VYSVILPVLI SASKLCDLAE LQRLNKNLKV DTESLPKYQW IAGQLEQNCM  60
   61 TADPASENMS DVIQLANQIY YKIGLIQLSN DQHLRAINTF EKIVFNETYK GSFGKLAEKR 120
  121 LQELYVDFGM WDKVHQKDDQ YAKYLSLNET IRNKISSKDV SVEEDISELL RITPYDVNVL 180
  181 STHIDVLFHK LAEEIDVSLA AAIILDYETI LDKHLASLSI DTRLSIHYVI SVLQTFVLNS 240
  241 DASFNIRKCL SIDMDYDKCK KLSLTISKLN KVNPSKRQIL DPATYAFENK KFRSWDRIIE 300
  301 FYLKDKKPFI TPMKILNKDT NFKNNYFFLE EIIKQLIEDV QLSRPLAKNL FEDPPITDGF 360
  361 VKPKSYYHTD YLVYIDSILC QASSMSPDVK RAKLAAPFCK KSLRHSLTLE TWKHYQDAKS 420
  421 EQKPLPETVL SDVWNSNPHL LMYMVNSILN KSRSKPHSQF KKQLYDQINK FFQDNGLSES 480
  481 TNPYVMKNFR LLQKQLQTYK EHKHRNFNQQ YFQQQQQQQQ HQRHQAPPAA PNYDPKKDYY 540
  541 KILGVSPSAS SKEIRKAYLN LTKKYHPDKI KANHNDKQES IHETMSQINE AYETLSDDDK 600
  601 RKEYDLSRSN PRRNTFPQGP RQNNMFKNPG SGFPFGNGFK MNFGL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data JEM1 Sundin BA, et al. (2004)
    View Data JEM1 Sundin BA, et al. (2004)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] deduced N/A No confident structure predictions are available.
    2 View Details [112..310] PSI-BLAST 6.69897 Protein phosphatase 5
    3 View Details [311..369] deduced N/A No confident structure predictions are available.
    4 View Details [370..531] MSA 2.264996 View MSA. No confident structure predictions are available.
    5 View Details [532..645] PSI-BLAST 141.28043 DnaJ chaperone, N-terminal (J) domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.14253214573541 bayes_pls_golite062009
  • protein binding
    		•  1.83529176977066 bayes_pls_golite062009
  • heat shock protein binding
    		•  1.35268080101836 bayes_pls_golite062009
  • unfolded protein binding
    		•  1.03065657981002 bayes_pls_golite062009
  • soluble NSF attachment protein activity
    		•  0.87758140474425 bayes_pls_golite062009
  • hydrolase activity
    		•  0.446391173448268 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.42893085337736 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.422422877754753 bayes_pls_golite062009
  • DNA binding
    		•  0.2126480534609 bayes_pls_golite062009
    2
    Term Confidence Notes
  • unfolded protein binding
    		•  3.04403163860617 bayes_pls_golite062009
  • heat shock protein binding
    		•  2.17994194200939 bayes_pls_golite062009
  • binding
    		•  2.0541759325193 bayes_pls_golite062009
  • protein binding
    		•  1.81676109739118 bayes_pls_golite062009
  • chaperone binding
    		•  1.61155546076854 bayes_pls_golite062009
  • Hsp70 protein binding
    		•  0.541755903922701 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.435350029200482 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.374102625114103 bayes_pls_golite062009
  • DNA binding
    		•  0.1383523679652 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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