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View Structure Prediction Details

Protein: JEM1
Organism: Saccharomyces cerevisiae
Length: 645 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for JEM1.

Description E-value Query
Range		 Subject
Range
JEM1_YEAST - DnaJ-like chaperone JEM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=JEM1 PE=1 SV=3
JEM1 - DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane...
 0.0 [1..645] [48..692]
DNJC3_MOUSE - DnaJ homolog subfamily C member 3 OS=Mus musculus GN=Dnajc3 PE=1 SV=1
 2.0E-95 [184..643] [71..503]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 6.0E-95 [184..643] [71..503]
DNAJC3 - DnaJ (Hsp40) homolog, subfamily C, member 3
gi|168277460 - gi|168277460|dbj|BAG10708.1| DnaJ homolog, subfamily C, member 3 [synthetic construct]
 8.0E-95 [184..643] [71..503]
gi|8570528, gi|1... - gi|8570528|dbj|BAA86882.3| protein kinase inhibitor p58 [Rattus norvegicus], gi|11560030|ref|NP_0715...
 2.0E-93 [184..643] [71..503]
gi|18859261, gi|... - gi|18859261|ref|NP_571705.1| protein-kinase, interferon-inducible double stranded RNA dependent inhi...
 2.0E-82 [181..643] [73..501]
gi|17065024 - gi|17065024|gb|AAL32666.1| Unknown protein [Arabidopsis thaliana]
 2.0E-76 [88..604] [503..1058]

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Predicted Domain #1
Region A:
Residues: [1-111] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILISGYCLL VYSVILPVLI SASKLCDLAE LQRLNKNLKV DTESLPKYQW IAGQLEQNCM  60
   61 TADPASENMS DVIQLANQIY YKIGLIQLSN DQHLRAINTF EKIVFNETYK G

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.14253214573541 bayes_pls_golite062009
protein binding 1.83529176977066 bayes_pls_golite062009
heat shock protein binding 1.35268080101836 bayes_pls_golite062009
unfolded protein binding 1.03065657981002 bayes_pls_golite062009
soluble NSF attachment protein activity 0.87758140474425 bayes_pls_golite062009
hydrolase activity 0.446391173448268 bayes_pls_golite062009
nucleic acid binding 0.42893085337736 bayes_pls_golite062009
transcription regulator activity 0.422422877754753 bayes_pls_golite062009
DNA binding 0.2126480534609 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-310] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SFGKLAEKRL QELYVDFGMW DKVHQKDDQY AKYLSLNETI RNKISSKDVS VEEDISELLR  60
   61 ITPYDVNVLS THIDVLFHKL AEEIDVSLAA AIILDYETIL DKHLASLSID TRLSIHYVIS 120
  121 VLQTFVLNSD ASFNIRKCLS IDMDYDKCKK LSLTISKLNK VNPSKRQILD PATYAFENKK 180
  181 FRSWDRIIEF YLKDKKPFI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 6.69897
Match: 1a17__
Description: Protein phosphatase 5
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
unfolded protein binding 3.04403163860617 bayes_pls_golite062009
heat shock protein binding 2.17994194200939 bayes_pls_golite062009
binding 2.0541759325193 bayes_pls_golite062009
protein binding 1.81676109739118 bayes_pls_golite062009
chaperone binding 1.61155546076854 bayes_pls_golite062009
Hsp70 protein binding 0.541755903922701 bayes_pls_golite062009
nucleic acid binding 0.435350029200482 bayes_pls_golite062009
transcription regulator activity 0.374102625114103 bayes_pls_golite062009
DNA binding 0.1383523679652 bayes_pls_golite062009
catalytic activity 0.106988907594358 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [311-369] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPMKILNKDT NFKNNYFFLE EIIKQLIEDV QLSRPLAKNL FEDPPITDGF VKPKSYYHT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [370-531] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DYLVYIDSIL CQASSMSPDV KRAKLAAPFC KKSLRHSLTL ETWKHYQDAK SEQKPLPETV  60
   61 LSDVWNSNPH LLMYMVNSIL NKSRSKPHSQ FKKQLYDQIN KFFQDNGLSE STNPYVMKNF 120
  121 RLLQKQLQTY KEHKHRNFNQ QYFQQQQQQQ QHQRHQAPPA AP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [532-645] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NYDPKKDYYK ILGVSPSASS KEIRKAYLNL TKKYHPDKIK ANHNDKQESI HETMSQINEA  60
   61 YETLSDDDKR KEYDLSRSNP RRNTFPQGPR QNNMFKNPGS GFPFGNGFKM NFGL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 141.28043
Match: 1xbl__
Description: DnaJ chaperone, N-terminal (J) domain
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle