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Protein Overview: PEP8

General Information:
Name(s) found: PEP8 / YJL053W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 379 amino acids

    Gene Ontology:
    Cellular Component: endosome [IPILink to PubMed article]
    retromer complex [IPILink to PubMed article]
    Biological Process: protein retention in Golgi apparatus [IMPLink to PubMed article]
    retrograde transport, endosome to Golgi [IPILink to PubMed article]
    Molecular Function: protein transporter activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIFFKPPID IEILFDNEES RKHVDIATRS SNSSYKSMKE SLPVYEDGES LGGIVTLRVR  60
   61 DSKKVDHLGI KVSVIGSIDM LKSHGSGNSS SKKVTSSTSS SSSNGSVDVR KNSVDQFLCQ 120
  121 SYDLCPAGEL QHSQSFPFLF RDLSKRYESY KGKNVDVAYY VKVTVMRKST DISKIKRFWV 180
  181 YLYNSVTTAP NTLSANETKA TTNDIAGGNY AADNASDNTQ TKSTQGEAAD VNQVLPISHS 240
  241 NNEPKPVRLD IGIENCLHIE FEYAKSQYSL KEVIVGRIYF LLTRLRIKHM ELSLITRESS 300
  301 GLQTSNVMTD STAIRYEIMD GSSVKGETIP IRLFLSGYDL TPNMSCNYFN VKNYLSLVII 360
  361 DEDGRRYFKQ SEITLYRTR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PEP8 VPS29 VPS35 VPS5
    View Details (MIPS) Mewes HW, et al. (2004) PEP8 VPS29 VPS35
    View Details Krogan NJ, et al. (2006) MIA40 MUK1 PEP8 VPS17 VPS29 VPS35 VPS5
    View Details Qiu et al. (2008) PEP8 VPS17 VPS29 VPS35 VPS5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #04 Alpha Factor Prep2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PEP8 Huh WK, et al. (2003)
    View Data PEP8 and SNF7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..188] ORFEUS 13.43 Arrestin
    2 View Details [189..379] ORFEUS 13.43 Arrestin


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle