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Protein Overview: VPS29

General Information:
Name(s) found: VPS29 / YHR012W [SGD]
Description(s) found:
Found 23 descriptions.
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  • Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 282 amino acids

    Gene Ontology:
    Cellular Component: endosome [IPILink to PubMed article]
    retromer complex [IPILink to PubMed article]
    Biological Process: retrograde transport, endosome to Golgi [IPILink to PubMed article]
    Molecular Function: protein transporter activity [IMPLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLLALSDAH IPDRATDLPV KFKKLLSVPD KISQVALLGN STKSYDFLKF VNQISNNITI  60
   61 VRGEFDNGHL PSTKKDKASD NSRPMEEIPM NSIIRQGALK IGCCSGYTVV PKNDPLSLLA 120
  121 LARQLDVDIL LWGGTHNVEA YTLEGKFFVN PGSCTGAFNT DWPIVFDVED SDEAVTSEVD 180
  181 KPTKENQSED DDAKGGSTGK EQPGSYTPKE GTAGERENEN ESNVKPENQF KEDEVDMSDS 240
  241 DINGSNSPSF CLLDIQGNTC TLYIYLYVNG EVKVDKVVYE KE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PEP8 VPS17 VPS29 VPS35 VPS5
    View Details (MIPS) Mewes HW, et al. (2004) PEP8 VPS29 VPS35
    View Details Krogan NJ, et al. (2006) MIA40 MUK1 PEP8 VPS17 VPS29 VPS35 VPS5
    View Details Gavin AC, et al. (2006) VPS29 VPS35 VPS5
    View Details Gavin AC, et al. (2002) VPS29 VPS35
    View Details Qiu et al. (2008) PEP8 VPS17 VPS29 VPS35 VPS5

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data VPS29 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..222] PSI-BLAST 13.221849 Mre11
    2 View Details [223..282] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  2.15398287574737 bayes_pls_golite062009
  • protein transporter activity
    		•  1.31841400137462 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  1.23826159413064 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.13357344565764 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.09206313505563 bayes_pls_golite062009
  • phosphatase activity
    		•  1.08894272596476 bayes_pls_golite062009
  • binding
    		•  1.0086165150304 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.783004917746429 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  0.521298686118866 bayes_pls_golite062009
  • protein binding
    		•  0.306836734324834 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle