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Protein Overview: STB5

General Information:
Name(s) found: STB5 / YHR178W [SGD]
Description(s) found:
Found 25 descriptions.
SHOW ALL
  • Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 743 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article]
    Biological Process: transcription [IDALink to PubMed article]
    response to drug [IMPLink to PubMed article]
    response to xenobiotic stimulus [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGPNFAHQG GRSQRTTELY SCARCRKLKK KCGKQIPTCA NCDKNGAHCS YPGRAPRRTK  60
   61 KELADAMLRG EYVPVKRNKK VGKSPLSTKS MPNSSSPLSA NGAITPGFSP YENDDAHKMK 120
  121 QLKPSDPINL VMGASPNSSE GVSSLISVLT SLNDNSNPSS HLSSNENSMI PSRSLPASVQ 180
  181 QSSTTSSFGG YNTPSPLISS HVPANAQAVP LQNNNRNTSN GDNGSNVNHD NNNGSTNTPQ 240
  241 LSLTPYANNS APNGKFDSVP VDASSIEFET MSCCFKGGRT TSWVREDGSF KSIDRSLLDR 300
  301 FIAAYFKHNH RLFPMIDKIA FLNDAATITD FERLYDNKNY PDSFVFKVYM IMAIGCTTLQ 360
  361 RAGMVSQDEE CLSEHLAFLA MKKFRSVIIL QDIETVRCLL LLGIYSFFEP KGSSSWTISG 420
  421 IIMRLTIGLG LNRELTAKKL KSMSALEAEA RYRVFWSAYC FERLVCTSLG RISGIDDEDI 480
  481 TVPLPRALYV DERDDLEMTK LMISLRKMGG RIYKQVHSVS AGRQKLTIEQ KQEIISGLRK 540
  541 ELDEIYSRES ERRKLKKSQM DQVERENNST TNVISFHSSE IWLAMRYSQL QILLYRPSAL 600
  601 MPKPPIDSLS TLGEFCLQAW KHTYTLYKKR LLPLNWITLF RTLTICNTIL YCLCQWSIDL 660
  661 IESKIEIQQC VEILRHFGER WIFAMRCADV FQNISNTILD ISLSHGKVPN MDQLTRELFG 720
  721 ASDSYQDILD ENNVDVSWVD KLV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data STB5 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 33.201249 CD2-Lac9
    2 View Details [112..175] deduced N/A No confident structure predictions are available.
    3 View Details [176..743] MSA 8.113966 View MSA. No confident structure predictions are available.
    4 View Details [493..743] MSA 3.257996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.93914501897006 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.44382866473054 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.87955444697212 bayes_pls_golite062009
  • transcription activator activity
    		•  0.915626626047549 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle