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View Structure Prediction Details

Protein: STB5
Organism: Saccharomyces cerevisiae
Length: 743 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STB5.

Description E-value Query
Range
Subject
Range
STB5 - Transcription factor, involved in regulating multidrug resistance and oxidative stress response; for...
STB5_YEAST - Protein STB5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STB5 PE=1 SV=1
0.0 [1..743] [1..743]
gi|245224 - gi|245224|gb|AAB21394.1| NIT4=protein product involved in nitrate assimilation [Neurospora intermedi...
NIT4_NEUCR - Nitrogen assimilation transcription factor nit-4 - Neurospora crassa
2.0E-77 [70..736] [2..673]
gi|6901427 - gi|6901427|emb|CAB71797.1| pathway-specific nitrogen regulator [Tolypocladium inflatum]
3.0E-77 [53..736] [4..689]
UAY_EMENI - Positive regulator of purine utilization - Emericella nidulans (Aspergillus nidulans)
3.0E-76 [4..726] [49..820]
gi|166488 - gi|166488|gb|AAA32686.1| regulatory protein
4.0E-74 [5..733] [2..645]
LAC9_KLULA - Lactose regulatory protein LAC9 OS=Kluyveromyces lactis GN=LAC9 PE=1 SV=1
LAC9_KLULA - Lactose regulatory protein LAC9 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / N...
1.0E-71 [4..738] [76..792]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
5.0E-71 [4..738] [76..792]
SPAC3C7.04 - transcription factor
YF54_SCHPO - Uncharacterized transcriptional regulatory protein C3C7.04 OS=Schizosaccharomyces pombe (strain 972 ...
7.0E-71 [14..691] [32..641]

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Predicted Domain #1
Region A:
Residues: [1-111]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGPNFAHQG GRSQRTTELY SCARCRKLKK KCGKQIPTCA NCDKNGAHCS YPGRAPRRTK  60
   61 KELADAMLRG EYVPVKRNKK VGKSPLSTKS MPNSSSPLSA NGAITPGFSP Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 33.201249
Match: 1cld__
Description: CD2-Lac9
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.93914501897006 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.44382866473054 bayes_pls_golite062009
sequence-specific DNA binding 1.87955444697212 bayes_pls_golite062009
transcription activator activity 0.915626626047549 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [112-175]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENDDAHKMKQ LKPSDPINLV MGASPNSSEG VSSLISVLTS LNDNSNPSSH LSSNENSMIP  60
   61 SRSL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [176-743]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PASVQQSSTT SSFGGYNTPS PLISSHVPAN AQAVPLQNNN RNTSNGDNGS NVNHDNNNGS  60
   61 TNTPQLSLTP YANNSAPNGK FDSVPVDASS IEFETMSCCF KGGRTTSWVR EDGSFKSIDR 120
  121 SLLDRFIAAY FKHNHRLFPM IDKIAFLNDA ATITDFERLY DNKNYPDSFV FKVYMIMAIG 180
  181 CTTLQRAGMV SQDEECLSEH LAFLAMKKFR SVIILQDIET VRCLLLLGIY SFFEPKGSSS 240
  241 WTISGIIMRL TIGLGLNREL TAKKLKSMSA LEAEARYRVF WSAYCFERLV CTSLGRISGI 300
  301 DDEDITVPLP RALYVDERDD LEMTKLMISL RKMGGRIYKQ VHSVSAGRQK LTIEQKQEII 360
  361 SGLRKELDEI YSRESERRKL KKSQMDQVER ENNSTTNVIS FHSSEIWLAM RYSQLQILLY 420
  421 RPSALMPKPP IDSLSTLGEF CLQAWKHTYT LYKKRLLPLN WITLFRTLTI CNTILYCLCQ 480
  481 WSIDLIESKI EIQQCVEILR HFGERWIFAM RCADVFQNIS NTILDISLSH GKVPNMDQLT 540
  541 RELFGASDSY QDILDENNVD VSWVDKLV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [493-743]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDDLEMTKLM ISLRKMGGRI YKQVHSVSAG RQKLTIEQKQ EIISGLRKEL DEIYSRESER  60
   61 RKLKKSQMDQ VERENNSTTN VISFHSSEIW LAMRYSQLQI LLYRPSALMP KPPIDSLSTL 120
  121 GEFCLQAWKH TYTLYKKRLL PLNWITLFRT LTICNTILYC LCQWSIDLIE SKIEIQQCVE 180
  181 ILRHFGERWI FAMRCADVFQ NISNTILDIS LSHGKVPNMD QLTRELFGAS DSYQDILDEN 240
  241 NVDVSWVDKL V

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle