Protein Overview: HXT1

General Information:
Name(s) found:	HXT1 / YHR094C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321886\|ref\|NP_011962.1\| Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; Hxt1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S38798 hexose transport protein HXT1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|487939\|gb\|AAB68933.1\| Hxt1p: High affinity hexose transporter [Saccharomyces cerevisiae] [NCBI NR] gi\|417163\|sp\|P32465.1\|HXT1_YEAST RecName: Full=Low-affinity glucose transporter HXT1 [NCBI NR] gi\|171670\|gb\|AAB59311.1\| hexose transporter [Saccharomyces cerevisiae] [NCBI NR] Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae GN=HXT1 PE=1 SV=1 [Swiss-Prot] HXT1 Low-affinity hexose facilitator [mips] Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting [SGD] HXT1, Chr VIII from 290915-292627, reverse complement [yeast_orfs2] Chr VIII from 290915-292627, reverse complement [yeastorf3.fasta] Chr VIII from 292627-290915, reverse complement [yeastorf5.fasta] (P32465) Low-affinity glucose transporter HXT1 [4932.FASTACCERV.txt] HXT1 SGDID:S0001136, Chr VIII from 292627-290915, reverse complement, Verified ORF [yeastflysequest.fasta] Hxt1p [Saccharomyces cerevisiae]gi\|417163\|sp\|P32465\|HXT1_YEAST Low-affinity glucose transporter HXT1gi\|487939\|gb\|AAB68933.1\| Hxt1p: High affinity hexose transporter [Saccharomyces cerevisiae]gi\|171670\|gb\|AAB59311.1\| hexose transportergi\|625543\|pir\|\|S3 [nrdb_11152004_Chlamydomonas] HXT1 SGDID:S000001136, Chr VIII from 292628-290916, reverse complement, Verified ORF, "Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Low-affinity glucose transporter HXT1 [nr-271106-contam.fasta] Hxt1p: High affinity hexose transporter [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; Hxt1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] hexose transporter [nr-271106-contam.fasta] HXT1 SGDID:S000001136, Chr VIII from 292628-290916, reverse complement, Verified ORF, "Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] HXT1 SGDID:S000001136, Chr VIII from 292625-290913, Genome Release 64-1-1, reverse complement, Verified ORF, "Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting" [yeast-030211-contam.fasta] HXT1 SGDID:S000001136, Chr VIII from 292625-290913, Genome Release 64-2-1, reverse complement, Verified ORF, "Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication" [20141208_orf_trans.fasta] YHR094C SGDID:S000001136, Chr VIII from 292625-290913, Genome Release 64-1-1, reverse complement, Verified ORF, "Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	570 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IDA]
Biological Process:	hexose transport [TAS]
Molecular Function:	galactose transmembrane transporter activity [TAS] fructose transmembrane transporter activity [IMP] glucose transmembrane transporter activity [TAS] mannose transmembrane transporter activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSTPDLISP QKSNSSNSYE LESGRSKAMN TPEGKNESFH DNLSESQVQP AVAPPNTGKG  60
   61 VYVTVSICCV MVAFGGFIFG WDTGTISGFV AQTDFLRRFG MKHHDGSHYL SKVRTGLIVS 120
  121 IFNIGCAIGG IVLAKLGDMY GRRIGLIVVV VIYTIGIIIQ IASINKWYQY FIGRIISGLG 180
  181 VGGITVLSPM LISEVAPSEM RGTLVSCYQV MITLGIFLGY CTNFGTKNYS NSVQWRVPLG 240
  241 LCFAWALFMI GGMMFVPESP RYLVEAGRID EARASLAKVN KCPPDHPYIQ YELETIEASV 300
  301 EEMRAAGTAS WGELFTGKPA MFQRTMMGIM IQSLQQLTGD NYFFYYGTIV FQAVGLSDSF 360
  361 ETSIVFGVVN FFSTCCSLYT VDRFGRRNCL MWGAVGMVCC YVVYASVGVT RLWPNGQDQP 420
  421 SSKGAGNCMI VFACFYIFCF ATTWAPIAYV VISECFPLRV KSKCMSIASA ANWIWGFLIS 480
  481 FFTPFITGAI NFYYGYVFMG CMVFAYFYVF FFVPETKGLS LEEVNDMYAE GVLPWKSASW 540
  541 VPVSKRGADY NADDLMHDDQ PFYKSLFSRK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		HXT1 HXT10 HXT3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC4	HXT1	1	Unpublished Fields Lab Data
View Screen	CMK1	HXT1	1	Unpublished Fields Lab Data
View Screen	YLR224W	HXT1	1	Unpublished Fields Lab Data
View Screen	FAR10	HXT1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..257] [306..517]	PSI-BLAST	468.0	No description for 1ja5A_ was found.
2	View Details	[258..305] [518..570]	PSI-BLAST	468.0	No description for 1ja5A_ was found.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
glycerol transmembrane transporter activity	7.11654923455995	bayes_pls_golite062009
alcohol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
polyol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity	5.74077413704789	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	2.63293544825311	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
binding	1.89539096965643	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
sugar binding	0.285073104957756	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2