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Protein Overview: NPR3

General Information:
Name(s) found: NPR3 / YHL023C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Component, with Npr2p, of an evolutionarily conserved complex that mediates downregulation of TOR Complex 1 activity in response to amino acid limitation; null mutant displays delayed meiotic DNA replication and double-strand break repair [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1146 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDECLPNSCL LGVHLVISTH SGPQIVYHYP PSNTAFLTNN PTKHQHLYGN HANLNKNTST  60
   61 NKEEKLFNSG STKTASQIAL NESAKSYNTA ITPSMTNTNT NNVTLPPTRS HANTVGSQSS 120
  121 IPAATNGVGY RKTDIEDTSR TFQYQETESE TSSSGLSDSE LSTDYLDISS DSFSISSSLS 180
  181 SSSLSSSPSS SSSSSPPQDG LSRTNSSFQS TDSMSPTSPQ MIMENDSISV AESYLDSGTN 240
  241 NKSRAASKRS QNFFHKLSTK KSTDSKTHSP VRKLKSKPSQ STKKGNKLLK NTSNETDGNA 300
  301 FTGSCSISSK KSLSSTGEHN QELRNSSLND TPGQSPHHYH HRYHHYHKNA ATSQRNSHTQ 360
  361 YDVEEEDMEV SAMLQDGKIS MNEIFFEEEN FQDINKILEF DNDFVAEFCS PEREMCNTRF 420
  421 EFTVDNFCFL GLPIHVDSQG RWRKSKHKNK TRSKRSSSTT TNISRKKSIA SKISSLSENT 480
  481 LKKVNSGEAD TVYDSNIGHE ASTDTPNLRI NTDVSGNEFE REKEDLGKNM NMFHVCFVMN 540
  541 PHLIEYNKRI DDMYQFVVTR LSLLLRYVQS KTSYISSECH IILKEKERVL KHSKTYQSIR 600
  601 GAGNKGKYLY QRILAKSSLA RALTECVDKI QRNEIACLEI NDDKVISLQI PIQNEFEKMP 660
  661 NFKLQPVLRG SYLTSILNMK FLEKSSLRIE SQNRQNDQAQ FSDTNNNIYR FGNNINSTGH 720
  721 CGAANVDDGD DNESNYYCDD NDDLLNYALL LLDEPNNIIS SLETFSYQDD IGTIILKHLV 780
  781 RNIQPNIPLR SYRYLITDLL DNPSSLDDLT TETNSLESSI LRSCALHLMY WRHARIVIPL 840
  841 SSKYTYIVSP LAPIQGYTID DYKSTSQNDG NVKKMDDREN NKSGSDRVPL IYQNSMLFRS 900
  901 KFPSLPSLPI FLSLLSTDKP QAYSNIIPSR EHKPVYLNAL AWLIQYGYVT QLLTFINIRV 960
  961 DKHIKMAVDE DLEKEGFRKT NTARRPSMDY KKTDKKLDDE DGQSRDANAS EACSGKNEGM1020
 1021 QSNDNNKDVD EKDNENDSRV DDRDDNEIAI ADEEEILHFE YDDPEMQHDY TIILEPERAT1080
 1081 AIEKRWLYRC IYGQPSDIQI LFNKLLKYFN GKVPMELVII KEEISRHDLK KLLNALDKYL1140
 1141 IEIHHW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..307] deduced N/A No confident structure predictions are available.
    2 View Details [308..1146] Pfam 4.920819 Uncharacterised protein family (UPF0171) No confident structure predictions are available.
    3 View Details [470..661] MSA 6.032991 View MSA. No confident structure predictions are available.
    4 View Details [662..742] deduced N/A No confident structure predictions are available.
    5 View Details [743..882] deduced N/A No confident structure predictions are available.
    6 View Details [883..989] deduced N/A No confident structure predictions are available.
    7 View Details [990..1060] deduced N/A No confident structure predictions are available.
    8 View Details [1061..1146] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.81

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle