Protein Overview: ETP1

General Information:
Name(s) found:	ETP1 / YHL010C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|731596\|sp\|P38748.1\|YHB0_YEAST RecName: Full=RING finger protein YHL010C [NCBI NR] gi\|6321777\|ref\|NP_011853.1\| Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences; Yhl010cp [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S46825 hypothetical protein YHL010c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|2289881\|gb\|AAB65064.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] RING finger protein YHL010C OS=Saccharomyces cerevisiae GN=YHL010C PE=1 SV=1 [Swiss-Prot] RING finger protein ETP1 OS=Saccharomyces cerevisiae GN=ETP1 PE=1 SV=1 [Swiss-Prot] Similarity to C.elegans hypothetical protein, homolog to human breast cancer-associated protein BRAP2 [mips] Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences [SGD] YHL010C, Chr VIII from 81959-83716, reverse complement [yeast_orfs2] Chr VIII from 81959-83716, reverse complement [yeastorf3.fasta] Chr VIII from 83716-81959, reverse complement [yeastorf5.fasta] (P38748) Hypothetical 67.5 kDa protein in PRPS4-STE20 intergenic region [4932.FASTACCERV.txt] YHL010C SGDID:S0001002, Chr VIII from 83716-81959, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] Yhl010cp [Saccharomyces cerevisiae]gi\|2289881\|gb\|AAB65064.1\| unknown [Saccharomyces cerevisiae]gi\|731596\|sp\|P38748\|YHB0_YEAST Hypothetical 67.5 kDa protein in PRPS4-STE20 intergenic regiongi\|626567\|pir\|\|S46825 hypothetical protein YHL010c - yeast (Sacc [nrdb_11152004_Chlamydomonas] YHL010C SGDID:S000001002, Chr VIII from 83717-81960, reverse complement, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YHL010C SGDID:S000001002, Chr VIII from 83717-81960, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localizat [yeast-contam.fasta] Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences; Yhl010cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] RING finger protein YHL010C [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ETP1 SGDID:S000001002, Chr VIII from 83717-81960, reverse complement, Verified ORF, "Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta] YHL010C SGDID:S000001002, Chr VIII from 83717-81960, reverse complement, Uncharacterized ORF, "Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences" [yeast-bovrabprots.fasta] [chemostatdb.fasta] ETP1 SGDID:S000001002, Chr VIII from 83717-81960, reverse complement, Verified ORF, "Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences" [SGDyeast.20101221.fasta] RING finger protein ETP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ETP1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ETP1 SGDID:S000001002, Chr VIII from 83721-81964, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences" [yeast-030211-contam.fasta] ETP1 SGDID:S000001002, Chr VIII from 83721-81964, Genome Release 64-2-1, reverse complement, Verified ORF, "Putative protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences" [20141208_orf_trans.fasta] YHL010C SGDID:S000001002, Chr VIII from 83721-81964, Genome Release 64-1-1, reverse complement, Verified ORF, "Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	585 amino acids
Gene Ontology:
Cellular Component:	cellular_component [ND]
Biological Process:	biological_process [ND]
Molecular Function:	nuclear localization sequence binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDQFEYIITL EFGNQNQVES AYQIFKSIPK KLKAKSIGEE SIKSNNQDWQ DWRVCDLEID  60
   61 MITDFKNQTS KEEESDLITS QYLGHGIIRL FKLSNANNTL NEKEILTIPG DDTMICILFV 120
  121 PTYFTVHDLL HFYIGDDIVN KQVSNFRILR NQQKGMGFNF TVLIKFRNAL DAKNFKEEFN 180
  181 GKSFSRMDPE TCHVISVKEI VFQKKLFQRP AANEDFPYLL TDPFTVKKKK ELVKVELPTC 240
  241 PVCLERMDSE TTGLVTIPCQ HTFHCQCLNK WKNSRCPVCR HSSLRLSRES LLKQAGDSAH 300
  301 CATCGSTDNL WICLICGNVG CGRYNSKHAI KHYEETLHCF AMDIRTQRVW DYAGDNYVHR 360
  361 LVQNEVDGKL VEVGGSGDDD NNDIGNSDEL QNVVYGNRSK NGEKSNSNKK DGELAANFLR 420
  421 HREYHLEYVQ VLISQLESQR EYYELKLQEK DQTASDSSNV ESLKKSMEDL KLQFQVTQKE 480
  481 WQKREMAQKS KLEEDMLVIE GLQANLDHLS KKQEQLEREN KALEESKQDL EEQVKDLMFY 540
  541 LDSQEKFKDA DESVKEGTIL IQQPHGAAQA SKSKKKRNKN KKAGK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		ETP1 MOH1 NHA1 YKR017C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LSM12	ETP1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..209]	deduced	N/A	No confident structure predictions are available.
2	View Details	[210..585]	PSI-BLAST	21.09691	Heavy meromyosin subfragment
3	View Details	[189..585]	PSI-BLAST	24.69897	Heavy meromyosin subfragment

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
binding	2.84044925655363	bayes_pls_golite062009
nucleic acid binding	2.16650337913343	bayes_pls_golite062009
RNA binding	1.55443392348354	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.3405047475504	bayes_pls_golite062009
small conjugating protein ligase activity	1.1717600698632	bayes_pls_golite062009
protein binding	1.05805521997665	bayes_pls_golite062009
acid-amino acid ligase activity	0.748751181289242	bayes_pls_golite062009
mRNA binding	0.372645027860457	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.205114038263623	bayes_pls_golite062009
hydrolase activity	0.181856784298799	bayes_pls_golite062009
protein phosphatase 2B binding	0.114018372525846	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2