Protein Overview: MAL11

General Information:
Name(s) found:	MAL11 / YGR289C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321729\|ref\|NP_011805.1\| Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; Mal11p [Saccharomyces cere [NCBI NR] pir\|\|S64624 alpha-glucoside transport protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1703215\|sp\|P53048.1\|MAL11_YEAST RecName: Full=General alpha-glucoside permease; AltName: Full=Maltose permease MAL11; AltName: Full=Maltose transport protein MAL11 [NCBI NR] gi\|1323529\|emb\|CAA97322.1\| AGT1 [Saccharomyces cerevisiae] [NCBI NR] General alpha-glucoside permease OS=Saccharomyces cerevisiae GN=MAL11 PE=1 SV=1 [Swiss-Prot] (P53048) General alpha-glucoside permease [Swiss-Prot] MAL11 Alpha-glucoside and threhalose permease [mips] Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; broad substrate specificity that includes maltotriose [SGD] MAL11, Chr VII from 1073960-1075810, reverse complement [yeast_orfs2] Chr VII from 1073960-1075810, reverse complement [yeastorf3.fasta] Chr VII from 1073967-1075817, reverse complement [yeastorf4.fasta] Chr VII from 1075817-1073967, reverse complement [yeastorf5.fasta] MAL11 SGDID:S0003521, Chr VII from 1075818-1073968, reverse complement, Verified ORF [yeastflysequest.fasta] MAL11 SGDID:S0003521, Chr VII from 1075819-1073969, reverse complement, Verified ORF [10112005cervSGD.fasta] Mal11p [Saccharomyces cerevisiae]gi\|1323529\|emb\|CAA97322.1\| AGT1 [Saccharomyces cerevisiae]gi\|2119801\|pir\|\|S64624 alpha-glucoside transport protein - yeast (Saccharomyces cerevisiae)gi\|1703215\|sp\|P53048\|MA11_YEAST General alpha-glucoside permease (Malt [nrdb_11152004_Chlamydomonas] MAL11 SGDID:S000003521, Chr VII from 1075819-1073969, reverse complement, Verified ORF, "Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] MAL11 SGDID:S000003521, Chr VII from 1075820-1073970, reverse complement, Verified ORF, "Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sug [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; Mal11p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] AGT1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] General alpha-glucoside permease (Maltose permease MAL11) (Maltose transport protein MAL11) [nr-271106-contam.fasta] MAL11 SGDID:S000003521, Chr VII from 1075820-1073970, reverse complement, Verified ORF, "Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; broad substrate specificity that includes maltotriose" [yeast-bovrabprots.fasta] MAL11 SGDID:S000003521, Chr VII from 1075819-1073969, reverse complement, Verified ORF, "Maltose permease, inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters" [yeast-contam_custom.fasta] [chemostatdb.fasta] General alpha-glucoside permease OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAL11 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MAL11 SGDID:S000003521, Chr VII from 1075813-1073963, Genome Release 64-1-1, reverse complement, Verified ORF, "Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization" [yeast-030211-contam.fasta] MAL11 SGDID:S000003521, Chr VII from 1075813-1073963, Genome Release 64-2-1, reverse complement, Verified ORF, "High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization" [20141208_orf_trans.fasta] YGR289C SGDID:S000003521, Chr VII from 1075813-1073963, Genome Release 64-1-1, reverse complement, Verified ORF, "Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	616 amino acids
Gene Ontology:
Cellular Component:	membrane fraction [TAS]
Biological Process:	trehalose transport [IDA] alpha-glucoside transport [TAS]
Molecular Function:	trehalose transmembrane transporter activity [IDA] alpha-glucoside:hydrogen symporter activity [IDA][TAS] maltose:hydrogen symporter activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNIISLVSK KKAASKNEDK NISESSRDIV NQQEVFNTED FEEGKKDSAF ELDHLEFTTN  60
   61 SAQLGDSDED NENVINEMNA TDDANEANSE EKSMTLKQAL LKYPKAALWS ILVSTTLVME 120
  121 GYDTALLSAL YALPVFQRKF GTLNGEGSYE ITSQWQIGLN MCVLCGEMIG LQITTYMVEF 180
  181 MGNRYTMITA LGLLTAYIFI LYYCKSLAMI AVGQILSAIP WGCFQSLAVT YASEVCPLAL 240
  241 RYYMTSYSNI CWLFGQIFAS GIMKNSQENL GNSDLGYKLP FALQWIWPAP LMIGIFFAPE 300
  301 SPWWLVRKDR VAEARKSLSR ILSGKGAEKD IQVDLTLKQI ELTIEKERLL ASKSGSFFNC 360
  361 FKGVNGRRTR LACLTWVAQN SSGAVLLGYS TYFFERAGMA TDKAFTFSLI QYCLGLAGTL 420
  421 CSWVISGRVG RWTILTYGLA FQMVCLFIIG GMGFGSGSSA SNGAGGLLLA LSFFYNAGIG 480
  481 AVVYCIVAEI PSAELRTKTI VLARICYNLM AVINAILTPY MLNVSDWNWG AKTGLYWGGF 540
  541 TAVTLAWVII DLPETTGRTF SEINELFNQG VPARKFASTV VDPFGKGKTQ HDSLADESIS 600
  601 QSSSIKQREL NAADKC

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		MAL11 MAL31

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	IST3	MAL11	1	Unpublished Fields Lab Data
View Screen	PEX1	MAL11	1	Unpublished Fields Lab Data
View Screen	CDC53	MAL11	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..94]	deduced	N/A	No confident structure predictions are available.
2	View Details	[95..299] [352..556]	PSI-BLAST	221.9691	No description for 1ja5A_ was found.
3	View Details	[300..351] [557..616]	PSI-BLAST	221.9691	No description for 1ja5A_ was found.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	2.52135563059944	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	2.52135563059944	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	1.6904339767429	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
binding	0.873217664940684	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2