Protein Overview: TNA1

General Information:
Name(s) found:	TNA1 / YGR260W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321698\|ref\|NP_011776.1\| High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); Tna1p [NCBI NR] pir\|\|S64593 probable membrane protein YGR260w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1723769\|sp\|P53322.1\|TNA1_YEAST RecName: Full=High-affinity nicotinic acid transporter; AltName: Full=Nicotinic acid permease [NCBI NR] gi\|1536952\|emb\|CAA69082.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|1323473\|emb\|CAA97289.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae GN=TNA1 PE=1 SV=1 [Swiss-Prot] TNA1 High affinity nicotinic acid plasma membrane permease [mips] High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) [SGD] TNA1, Chr VII from 1012482-1014086 [yeast_orfs2] Chr VII from 1012482-1014086 [yeastorf3.fasta] Chr VII from 1012489-1014093 [yeastorf4.fasta] (P53322) High-affinity nicotinic acid transporter (Nicotinic acid permease) [4932.FASTACCERV.txt] TNA1 SGDID:S0003492, Chr VII from 1012490-1014094, Verified ORF [yeastflysequest.fasta] TNA1 SGDID:S0003492, Chr VII from 1012491-1014095, Verified ORF [10112005cervSGD.fasta] High affinity nicotinic acid plasma membrane permease [Saccharomyces cerevisiae]gi\|1323473\|emb\|CAA97289.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|1536952\|emb\|CAA69082.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2132630\|pir\|\|S6 [nrdb_11152004_Chlamydomonas] TNA1 SGDID:S000003492, Chr VII from 1012491-1014095, Verified ORF, "High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic a [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] High-affinity nicotinic acid transporter (Nicotinic acid permease) [nr-271106-contam.fasta] High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); Tna1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] TNA1 SGDID:S000003492, Chr VII from 1012491-1014095, Verified ORF, "High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)" [yeast-bovrabprots.fasta] [chemostatdb.fasta] High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TNA1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] TNA1 SGDID:S000003492, Chr VII from 1012485-1014089, Genome Release 64-1-1, Verified ORF, "High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)" [yeast-030211-contam.fasta] TNA1 SGDID:S000003492, Chr VII from 1012485-1014089, Genome Release 64-2-1, Verified ORF, "High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)" [20141208_orf_trans.fasta] YGR260W SGDID:S000003492, Chr VII from 1012485-1014089, Genome Release 64-1-1, Verified ORF, "High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	534 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [ISS] mitochondrion [IDA ]
Biological Process:	nicotinamide mononucleotide transport [IEP][IMP] cell wall hydroxyproline-rich glycoprotein metabolic process [IEP][IMP]
Molecular Function:	nicotinamide mononucleotide transmembrane transporter activity [IEP][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKFTMESP KHLVDDVLFI SPTNDGSEEK PTEVTFQEDE GHDASLHNRS HDKKSELATE  60
   61 REIMATTTDD DGIPSPSHPM EKRVLRKMDI YLIPLMGMLY FLSNLDKSNI GNAEVAGLSK 120
  121 DIHLVGTQYN TCVTVFFATY VLFDPIGTNL LKIMGPPLMM SICLTCFGAI SLGTAWVKNY 180
  181 AQLIVVRLLL GAFEGMIYPA INMYLSVCYR REQYALRFAF VFSAACLSSS FGGLIAYGCS 240
  241 KISGSLKDWQ YIYIVEGCIS LGFVPFYAFG LSKNLEDSWF FNKEEKEYIS ERYKTMNTFD 300
  301 PDEKFEWFQV WQAVKDVKTW ASAVALFGID LTTFGLTVFL PIIITSMGFT NVRAQLMTVP 360
  361 IYFLTAIVFF ICAVWSDRIK LRSPFILGAC LTTSIGIAIV LGSQVHGVRY FGVYILCMGI 420
  421 YVNAACNCLW LSGNTGNYFK RATALGINLF FGSGSGLVSG QIFVAKDKPR YIKGLSISLA 480
  481 FQVFSIFMTV VQIFLYKREN DKKKAIIDRC NELGEPIPYD ERLSDKNPEF KYMY

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		AGP2 TNA1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LIA1	TNA1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	TNA1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..73]	deduced	N/A	No confident structure predictions are available.
2	View Details	[74..534]	PSI-BLAST	47.0	No description for 1ja5A_ was found.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	5.46247398538901	bayes_pls_golite062009
ion transmembrane transporter activity	4.58978526526921	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
anion transmembrane transporter activity	3.94605227012838	bayes_pls_golite062009
cation transmembrane transporter activity	3.88180006470231	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
inorganic anion transmembrane transporter activity	2.52916479889426	bayes_pls_golite062009
organic acid transmembrane transporter activity	2.15783210522667	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
polyol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.924836669821548	bayes_pls_golite062009
binding	0.873217664940684	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.812001619402678	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
phosphate transmembrane transporter activity	0.312628600969375	bayes_pls_golite062009
cation:sugar symporter activity	0.143419068761182	bayes_pls_golite062009
sugar:hydrogen symporter activity	0.143419068761182	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2