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View Structure Prediction Details

Protein: TNA1
Organism: Saccharomyces cerevisiae
Length: 534 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TNA1.

Description E-value Query
Range
Subject
Range
TNA1 - High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicot...
TNA1_YEAST - High-affinity nicotinic acid transporter OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...
gi|190406736 - gi|190406736|gb|EDV10003.1| high-affinity nicotinic acid transporter [Saccharomyces cerevisiae RM11-...
2.0E-94 [1..534] [1..534]
VGLU2_RAT - Vesicular glutamate transporter 2 OS=Rattus norvegicus GN=Slc17a6 PE=1 SV=1
4.0E-78 [31..530] [11..535]
ENSPTRT00000047022 - null
SLC17A6 - solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
6.0E-77 [37..530] [17..535]
KHT2_KLULC - Hexose transporter 2 OS=Kluyveromyces lactis GN=KHT2 PE=3 SV=1
1.0E-76 [23..517] [6..530]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-75 [85..519] [19..494]
STP1_ARATH - Sugar transport protein 1 OS=Arabidopsis thaliana GN=STP1 PE=1 SV=2
6.0E-75 [84..515] [18..490]

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Predicted Domain #1
Region A:
Residues: [1-73]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKFTMESP KHLVDDVLFI SPTNDGSEEK PTEVTFQEDE GHDASLHNRS HDKKSELATE  60
   61 REIMATTTDD DGI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
substrate-specific transmembrane transporter activity 5.46247398538901 bayes_pls_golite062009
ion transmembrane transporter activity 4.58978526526921 bayes_pls_golite062009
transporter activity 4.09176719149278 bayes_pls_golite062009
anion transmembrane transporter activity 3.94605227012838 bayes_pls_golite062009
cation transmembrane transporter activity 3.88180006470231 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
inorganic anion transmembrane transporter activity 2.52916479889426 bayes_pls_golite062009
organic acid transmembrane transporter activity 2.15783210522667 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
polyol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
alcohol transmembrane transporter activity 0.924836669821548 bayes_pls_golite062009
binding 0.873217664940684 bayes_pls_golite062009
glycerol transmembrane transporter activity 0.812001619402678 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
phosphate transmembrane transporter activity 0.312628600969375 bayes_pls_golite062009
cation:sugar symporter activity 0.143419068761182 bayes_pls_golite062009
sugar:hydrogen symporter activity 0.143419068761182 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [74-534]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSPSHPMEKR VLRKMDIYLI PLMGMLYFLS NLDKSNIGNA EVAGLSKDIH LVGTQYNTCV  60
   61 TVFFATYVLF DPIGTNLLKI MGPPLMMSIC LTCFGAISLG TAWVKNYAQL IVVRLLLGAF 120
  121 EGMIYPAINM YLSVCYRREQ YALRFAFVFS AACLSSSFGG LIAYGCSKIS GSLKDWQYIY 180
  181 IVEGCISLGF VPFYAFGLSK NLEDSWFFNK EEKEYISERY KTMNTFDPDE KFEWFQVWQA 240
  241 VKDVKTWASA VALFGIDLTT FGLTVFLPII ITSMGFTNVR AQLMTVPIYF LTAIVFFICA 300
  301 VWSDRIKLRS PFILGACLTT SIGIAIVLGS QVHGVRYFGV YILCMGIYVN AACNCLWLSG 360
  361 NTGNYFKRAT ALGINLFFGS GSGLVSGQIF VAKDKPRYIK GLSISLAFQV FSIFMTVVQI 420
  421 FLYKRENDKK KAIIDRCNEL GEPIPYDERL SDKNPEFKYM Y

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.0
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle