Protein Overview: MSP1

General Information:
Name(s) found:	MSP1 / YGR028W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321465\|ref\|NP_011542.1\| Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase; Msp1p [Saccharomyces cerevisiae] [NCBI NR] gi\|531756\|emb\|CAA56956.1\| YTA4 (=MSP1) [Saccharomyces cerevisiae] [NCBI NR] gi\|462627\|sp\|P28737.2\|MSP1_YEAST RecName: Full=Protein MSP1; AltName: Full=TAT-binding homolog 4 [NCBI NR] gi\|45269435\|gb\|AAS56098.1\| YGR028W [Saccharomyces cerevisiae] [NCBI NR] gi\|404217\|emb\|CAA48191.1\| MSP1 protein [Saccharomyces cerevisiae] [NCBI NR] pir\|\|A49506 MSP1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1323004\|emb\|CAA97015.1\| MSP1 [Saccharomyces cerevisiae] [NCBI NR] Protein MSP1 OS=Saccharomyces cerevisiae GN=MSP1 PE=1 SV=2 [Swiss-Prot] MSP1 Intra-mitochondrial sorting protein [mips] Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase [SGD] MSP1, Chr VII from 542197-543285 [yeast_orfs2] Chr VII from 542197-543285 [yeastorf3.fasta] Chr VII from 542204-543292 [yeastorf4.fasta] (P28737) MSP1 protein (TAT-binding homolog 4) [4932.FASTACCERV.txt] MSP1 SGDID:S0003260, Chr VII from 542205-543293, Verified ORF [yeastflysequest.fasta] MSP1 SGDID:S0003260, Chr VII from 542207-543295, Verified ORF [10112005cervSGD.fasta] 40 kDa putative membrane-spanning ATPase [Saccharomyces cerevisiae]gi\|1323004\|emb\|CAA97015.1\| MSP1 [Saccharomyces cerevisiae]gi\|404217\|emb\|CAA48191.1\| MSP1 protein [Saccharomyces cerevisiae]gi\|531756\|emb\|CAA56956.1\| YTA4 (=MSP1) [Saccharomyces cerevisi [nrdb_11152004_Chlamydomonas] MSP1 SGDID:S000003260, Chr VII from 542207-543295, Verified ORF, "Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] MSP1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase; Msp1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YTA4 (=MSP1) [Saccharomyces cerevisiae] [nr-271106-contam.fasta] MSP1 protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YGR028W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein MSP1 (TAT-binding homolog 4) [nr-271106-contam.fasta] [chemostatdb.fasta] Protein MSP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSP1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MSP1 SGDID:S000003260, Chr VII from 542203-543291, Genome Release 64-1-1, Verified ORF, "Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase" [yeast-030211-contam.fasta] MSP1 SGDID:S000003260, Chr VII from 542203-543291, Genome Release 64-2-1, Verified ORF, "Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extraction engine in local organelle surveillance to remove and initiate degradation of mistargeted proteins, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain" [20141208_orf_trans.fasta] YGR028W SGDID:S000003260, Chr VII from 542203-543291, Genome Release 64-1-1, Verified ORF, "Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	362 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial outer membrane [IDA ]
Biological Process:	protein targeting to mitochondrion [IGI]
Molecular Function:	ATPase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSRKFDLKTI TDLSVLVGTG ISLYYLVSRL LNDVESGPLS GKSRESKAKQ SLQWEKLVKR  60
   61 SPALAEVTLD AYERTILSSI VTPDEINITF QDIGGLDPLI SDLHESVIYP LMMPEVYSNS 120
  121 PLLQAPSGVL LYGPPGCGKT MLAKALAKES GANFISIRMS SIMDKWYGES NKIVDAMFSL 180
  181 ANKLQPCIIF IDEIDSFLRE RSSTDHEVTA TLKAEFMTLW DGLLNNGRVM IIGATNRIND 240
  241 IDDAFLRRLP KRFLVSLPGS DQRYKILSVL LKDTKLDEDE FDLQLIADNT KGFSGSDLKE 300
  301 LCREAALDAA KEYIKQKRQL IDSGTIDVND TSSLKIRPLK TKDFTKKLRM DATSTLSSQP 360
  361 LD

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		HSP78 MSP1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RRN10	MSP1	1	Unpublished Fields Lab Data
View Screen	NTA1	MSP1	1	Unpublished Fields Lab Data
View Screen	APC5	MSP1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MSP1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..87]	PSI-BLAST	478.0103	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
2	View Details	[88..257]	PSI-BLAST	478.0103	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
3	View Details	[258..362]	PSI-BLAST	478.0103	Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2