Protein Overview: NPY1

General Information:
Name(s) found:	NPY1 / YGL067W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6321371\|ref\|NP_011448.1\| NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; Npy1p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S64074 hypothetical protein YGL067w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1723847\|sp\|P53164.1\|NPY1_YEAST RecName: Full=NADH pyrophosphatase [NCBI NR] gi\|1322576\|emb\|CAA96771.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] NADH pyrophosphatase OS=Saccharomyces cerevisiae GN=NPY1 PE=1 SV=1 [Swiss-Prot] (P53164) NADH pyrophosphatase (EC 3.6.1.-) [Swiss-Prot] NPY1 NADH pyrophosphatase I of the Nudix family of hydrolases, has a peroxisomal targeting signal [mips] NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes [SGD] NPY1, Chr VII from 376099-377253 [yeast_orfs2] Chr VII from 376099-377253 [yeastorf3.fasta] Chr VII from 376102-377256 [yeastorf4.fasta] NPY1 SGDID:S0003035, Chr VII from 376102-377256, Verified ORF [yeastflysequest.fasta] NPY1 SGDID:S0003035, Chr VII from 376104-377258, Verified ORF [10112005cervSGD.fasta] NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes [Saccharomyces cerevisiae]gi\|1322576\|emb\|CAA96771.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2131578\|pir\|\|S [nrdb_11152004_Chlamydomonas] NPY1 SGDID:S000003035, Chr VII from 376104-377258, Verified ORF, "NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; Npy1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] NADH pyrophosphatase [nr-271106-contam.fasta] [chemostatdb.fasta] NADH pyrophosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NPY1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] NPY1 SGDID:S000003035, Chr VII from 376101-377255, Genome Release 64-1-1, Verified ORF, "NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes" [yeast-030211-contam.fasta] NPY1 SGDID:S000003035, Chr VII from 376101-377255, Genome Release 64-2-1, Verified ORF, "NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member" [20141208_orf_trans.fasta] YGL067W SGDID:S000003035, Chr VII from 376101-377255, Genome Release 64-1-1, Verified ORF, "NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	384 amino acids
Gene Ontology:
Cellular Component:	peroxisome [IDA] cytoplasm [IDA]
Biological Process:	NADH metabolic process [IDA]
Molecular Function:	NAD+ diphosphatase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTAVTFFGQ HVLNRVSFLR CSKEFIKKSL NHDSTVFIPF IEGEALISPE NGDLVQLSNS  60
   61 VKSYKNILSA IVPLYTTLLN TTRSRSDESG INVTFLGLLE GTDSAFNFEW SNISYKGTPY 120
  121 FGLDIRVTES TLFKKVDFEP IFSYPKVTRD HIFKQTNEDA SLYSQGKMYL DWLAKYKFCP 180
  181 GCGSPLFPVE AGTKLQCSNE NRNVYCNVRD ARINNVCFPR TDPTVIIALT NSDYSKCCLA 240
  241 RSKKRYGDFV LYSTIAGFME PSETIEEACI REIWEETGIS CKNIDIVRSQ PWPYPCSLMI 300
  301 GCLGIVQFNS KNEVINLNHD DELLDAQWFD TTEIIQALDK YAGGYRVPFK NDINLPGSTT 360
  361 IAFQLINHVC ENYKNLRKTS SSHL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		ALG5 BRE5 CSN12 CUP2 DBP7 LUG1 MET10 MSC7 MSE1 NOP53 NPY1 PBP4 RPF2 RRS1 SAS5 UME6 YGR126W YHR127W YPR045C YRA1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	TEL1	NPY1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	NPY1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..190]	MSA	1.038996	View MSA. No confident structure predictions are available.
2	View Details	[191..384]	PSI-BLAST	16.69897	ADP-ribose pyrophosphatase

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2