Protein Overview: YBP2

General Information:
Name(s) found:	YBP2 / YGL060W [SGD]
Description(s) found: Found 27 descriptions. SHOW ALL	Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	641 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	biological_process [ND]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYNEQVNSGK SIKEKERYLD ALLKILKDNP VTLKEIGWDL PKGLLQFFSR KNINVNIHLV  60
   61 FSPLVSSVME CFNELAINGN PKECLLTACE LVSTLHIVLT ETGDSDEENE DLNDSNRNDA 120
  121 SNITDELSVI TPEIGHYMAK NTVEFIPNLK IYVLFEFMSL LLKRVDTLYP SKFLAMVTSA 180
  181 IIKYVTTNVQ AMDDPHFILR IVYNFCTNYS PAQPSASLTD GISTNDLEKI HDDESALQKK 240
  241 LLANLSVFVI SNCLKNHPGN IDKIYFKTLM HKKTDENEID ASVLQICHQY YEYVTSLDVH 300
  301 MKELLEKCLV ESRSIYNSLL MNPAASTPEF KEEINQLVYE VSYAYQIKKL ADEKNLELDQ 360
  361 YGVVILSAIH YSKNGTHLLP QIDIQSAIYL YLRCTTASLF SEIYENKFLE SSVRYWLWVS 420
  421 TTETSTEKIK CALQELPGHI TTAFLQMLLM KTCNESNNDT KLTEITLLRR LLYLMPESTS 480
  481 FTFIFETLLH CPYITAKIAV LDILRDMMIR SPEAANRDET VGLIEQQNPG NTANSVPIMP 540
  541 TLPPRPYITI NEDRMASIHS IALICFSAAK QKKRTQGDLL LVLTYMKFFV SLRNKWDLGL 600
  601 LTLINKEISE SFQGEGEPEL AFINISNNTL GEYIEEMNIR S

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		MGE1 POR1 RVS161 RVS167 YBP2

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ASF1	3912: TAP-tagged, strain background includes hpc2(delta)	Green EM, et al (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	HRT1	YBP2	2	Unpublished Fields Lab Data
View Screen	SAS3	YBP2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YBP2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..50] [525..531]	ORFEUS	7.77	5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
2	View Details	[51..101]	ORFEUS	7.77	5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
3	View Details	[102..293] [347..524] [532..641]	ORFEUS	7.77	5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
4	View Details	[294..346]	ORFEUS	7.77	5' to 3' exonuclease domain of DNA polymerase Taq; Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
5	View Details	[543..641]	deduced	N/A	Confident ab initio structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.93

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2